Mean platelet volume is associated with serum 25-hydroxyvitamin D concentrations in patients with stable coronary artery disease
| Autor: | Mariusz Gąsior, Barbara Zubelewicz-Szkodzińska, Janusz Szkodzinski, Bartosz Hudzik, Jolanta Nowak, Ilona Korzonek-Szlacheta, Justyna Nowak |
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| Rok vydání: | 2018 |
| Předmět: |
Blood Platelets
Male medicine.medical_specialty Mean platelet volume 030209 endocrinology & metabolism Coronary Artery Disease 030204 cardiovascular system & hematology Gastroenterology vitamin D deficiency Coronary artery disease 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Vitamin D and neurology Humans Platelet Vitamin D Aged Aged 80 and over 25(OH)D Platelet Count business.industry medicine.disease Thrombosis Hemostasis Population study Female Original Article Cardiology and Cardiovascular Medicine business Biomarkers |
| Zdroj: | Heart and Vessels |
| ISSN: | 1615-2573 0910-8327 |
| DOI: | 10.1007/s00380-018-1182-9 |
| Popis: | There is little published data on the association of platelet function and 25(OH)D concentration. We investigated the associations between mean platelet volume (MPV) and 25(OH)D concentration in patients with stable coronary artery disease. Study population was divided into three groups: group 1—25(OH)D 20 ng/mL (N = 14). Study groups shared similar demographics. MPV values were the highest in group 1, moderate in group 2, and the lowest in group 3 (11.1 vs 10.4 vs 9.8 fL P 10.5 fL) for vitamin D deficiency and a weak predictive value (AUC 0.65) in identifying the discrimination thresholds of 25(OH)D concentration (≤ 15.5 ng/mL) for the presence of large platelets (MPV over the upper limit of normal). In conclusion, even though the effect of vitamin D on platelet size and function is probably multifactorial, our study provides further evidence linking vitamin D to thrombosis and hemostasis. Platelets are another potential element through which vitamin D deficiency could exert adverse cardiovascular outcomes. |
| Databáze: | OpenAIRE |
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