Genome-wide identification of enhancer elements in the placenta
| Autor: | Majd Abdulghani, Geetu Tuteja, Ashish Jain |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Placenta ATAC-seq Computational biology Biology Genome DNase-Seq Article 03 medical and health sciences 0302 clinical medicine Pregnancy Transcriptional regulation medicine Animals Humans Enhancer Regulation of gene expression 030219 obstetrics & reproductive medicine Genome Human Obstetrics and Gynecology Placentation 030104 developmental biology medicine.anatomical_structure Enhancer Elements Genetic Reproductive Medicine FAIRE-Seq Female Developmental Biology |
| Zdroj: | Placenta. 79 |
| ISSN: | 1532-3102 |
| Popis: | Normal placental development is essential for a healthy pregnancy, and is contingent upon tight spatiotemporal regulation of gene expression. One level of transcriptional control is via enhancer elements in the genome. Enhancers are distal cis-regulatory elements that can impact gene expression regardless of their position or orientation. The study of enhancers in the placenta is usually focused on one or two at a time, and the simultaneous identification of all enhancers has been limited. However, such a holistic approach is necessary if we are to gain a systems-level understanding of gene expression regulation in the placenta. Here, we review current methods for genome-scale enhancer identification, as well as studies that have applied those techniques in the placenta, with the aim of guiding future research. |
| Databáze: | OpenAIRE |
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