Flow injection chemiluminescent determination of amiodarone in pharmaceutical preparations using photogenerated tris(2,2′-bipyridyl)ruthenium(III)
| Autor: | Carmen Martínez-Lozano, Jesús Martín, Encarna Ruiz, Tomás Pérez-Ruiz |
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| Rok vydání: | 2006 |
| Předmět: |
Tris
Clinical Biochemistry Analytical chemistry Amiodarone Pharmaceutical Science chemistry.chemical_element Sensitivity and Specificity Analytical Chemistry law.invention chemistry.chemical_compound law Peroxydisulfate Drug Discovery Organometallic Compounds Spectroscopy Chemiluminescence Flow injection analysis Detection limit Hydrogen-Ion Concentration Ruthenium chemistry Reagent Flow Injection Analysis Luminescent Measurements Quantitative analysis (chemistry) Nuclear chemistry |
| Zdroj: | Journal of Pharmaceutical and Biomedical Analysis. 42:143-147 |
| ISSN: | 0731-7085 |
| DOI: | 10.1016/j.jpba.2005.12.031 |
| Popis: | A flow injection configuration was developed and evaluated for the chemiluminescent determination of amiodarone. The method is based on the reaction of the drug with tris(2,2'-bipyridyl)ruthenium(III), which was generated through the on-line photo-oxidation of tris(2,2'-bipyridyl)ruthenium(II) with peroxydisulfate. Under the optimum experimental conditions, a linear calibration graph was obtained over the range 3.0-60.0 microg ml(-1) with a detection limit of 0.28 microg ml(-1). The proposed method allows 120 injections h(-1) with excellent repeatability and precision (R.S.D. less than 0.5% and 2.8%, respectively) and a reagent consumption of only 0.37 micromol (0.27 mg) of Ru(bpy)(3)Cl(2) x 6H(2)O per determination. The method was successfully applied to the determination of amiodarone in commercial pharmaceutical formulations. |
| Databáze: | OpenAIRE |
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