Molecular identification, expression and prognostic role of estrogen- And progesterone receptors in head and neck cancer
| Autor: | Erzsébet Rásó, Júlia Lukits, Éva Remenár, Miklós Kásler, A. Ladányi, József Tímár |
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| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty medicine.drug_class Estrogen receptor Biology Polymerase Chain Reaction Cohort Studies Internal medicine Progesterone receptor medicine Humans Receptor Aged Neoplasm Staging Aged 80 and over Oncogene Cancer Sex hormone receptor Middle Aged Prognosis medicine.disease Survival Analysis Molecular medicine Neoplasm Proteins Endocrinology Receptors Estrogen Oncology Head and Neck Neoplasms Estrogen Disease Progression Cancer research Female Receptors Progesterone hormones hormone substitutes and hormone antagonists |
| Zdroj: | Scopus-Elsevier |
| Popis: | The aims of this study were to assess the sex hormone receptor status of head and neck (HNC) cancers. Frozen surgical samples (n = 67) of HNC patients were analyzed. Protein expression of estrogen receptor (ER)alpha, ERbeta and progesterone receptor (PgR) of tumor cells was determined by immunocytochemistry. Data were confirmed at mRNA level by nested-PCR and sequencing. ER and PgR expressions confirmed by PCR analysis were frequent in HNC: 50.7 and 49.3% respectively. Concerning the ER isoforms, ERalpha expression was predominant over ERbeta in both of oral cavity- as well as laryngeal/hypopharyngeal (LH) cancers. The delta3 splice variant of ERalpha was detected at low frequency, while the delta5 splice variant of ERbeta was frequent in HNC. The incidence of functional receptor expression (coexpression of ER and PgR) was relatively frequent also in HNC (27/67, 40.3%) which was independent of the anatomical location of the tumor. Sex hormone receptor expressions did not affect survival of HNC patients, however, in the LH cancer subgroup ER expression was associated with a trend of shortened survival (p = 0.0636, Mantel-Cox generalized savage). ERalpha,beta and PgR expressions are frequent in HNC and may affect the prognosis of the disease, at least in case of LH cancers. |
| Databáze: | OpenAIRE |
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