Boron-exposed male workers in Turkey: no change in sperm Y:X chromosome ratio and in offspring’s sex ratio

Autor: Kaan Aydos, Nurşen Başaran, Can Özgür Yalçın, Merve Bacanlı, Matthias Werner, Tanja Schwerdtle, Sevtap Aydin, Aylin Üstündağ, Cem Somer Atabekoğlu, Hermann M. Bolt, Yalçın Duydu, Katja Ickstadt, Hatice Gül Anlar, Klaus Golka
Rok vydání: 2019
Předmět:
Zdroj: Archives of Toxicology. 93:743-751
ISSN: 1432-0738
0340-5761
DOI: 10.1007/s00204-019-02391-z
Popis: Boron-associated shifts in sex ratios at birth were suggested earlier and attributed to a decrease in Y- vs. X-bearing sperm cells. As the matter is pivotal in the discussion of reproductive toxicity of boron/borates, re-investigation in a highly borate-exposed population was required. In the present study, 304 male workers in Bandirma and Bigadic (Turkey) with different degrees of occupational and environmental exposure to boron were investigated. Boron was quantified in blood, urine and semen, and the persons were allocated to exposure groups along B blood levels. In the highest (“extreme”) exposure group (n = 69), calculated mean daily boron exposures, semen boron and blood boron concentrations were 44.91 ± 18.32 mg B/day, 1643.23 ± 965.44 ng B/g semen and 553.83 ± 149.52 ng B/g blood, respectively. Overall, an association between boron exposure and Y:X sperm ratios in semen was not statistically significant (p > 0.05). Also, the mean Y:X sperm ratios in semen samples of workers allocated to the different exposure groups were statistically not different in pairwise comparisons (p > 0.05). Additionally, a boron-associated shift in sex ratio at birth towards female offspring was not visible. In essence, the present results do not support an association between boron exposure and decreased Y:X sperm ratio in males, even under extreme boron exposure conditions.
Databáze: OpenAIRE
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