| Autor: |
Xue-Quan Zhou, Peiyuan Wang, Vadde Ramu, Liyan Zhang, Suhua Jiang, Xuezhao Li, Selda Abyar, Panagiota Papadopoulou, Yang Shao, Ludovic Bretin, Maxime A. Siegler, Francesco Buda, Alexander Kros, Jiangli Fan, Xiaojun Peng, Wen Sun, Sylvestre Bonnet |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Popis: |
Self-assembling molecular drugs combine the easy preparation typical of small-molecule chemotherapy and the tumour-targeting properties of drug–nanoparticle conjugates. However, they require a supramolecular interaction that survives the complex environment of a living animal. Here we report that the metallophilic interaction between cyclometalated palladium complexes generates supramolecular nanostructures in living mice that have a long circulation time (over 12 h) and efficient tumour accumulation rate (up to 10.2% of the injected dose per gram) in a skin melanoma tumour model. Green light activation leads to efficient tumour destruction due to the type I photodynamic effect generated by the self-assembled palladium complexes, as demonstrated in vitro by an up to 96-fold cytotoxicity increase upon irradiation. This work demonstrates that metallophilic interactions are well suited to generating stable supramolecular nanotherapeutics in vivo with exceptional tumour-targeting properties. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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