Polymerization of a peptide-based enzyme substrate
| Autor: | Nathan C. Gianneschi, Michael E. Hahn, Lyndsay M. Randolph, Lisa Adamiak, Matthew P. Thompson |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Peptide
Metathesis Article Catalysis Polymerization Amphiphile Materials Chemistry Humans Organic chemistry chemistry.chemical_classification Metals and Alloys Substrate (chemistry) General Chemistry Polymer ROMP Combinatorial chemistry Enzymes Surfaces Coatings and Films Electronic Optical and Magnetic Materials Enzyme chemistry Proteolysis Ceramics and Composites Nanoparticles Oligopeptides |
| Zdroj: | Chemical Communications. 49:2873 |
| ISSN: | 1364-548X 1359-7345 |
| Popis: | Polymers of norbornenyl-modified peptide-based enzyme substrates have been prepared via ring-opening metathesis polymerization (ROMP). Peptides displayed on water-soluble homopolymers retain the ability to be enzymatically processed by a disease-associated enzyme. In contrast, when the peptides are densely arrayed on a nanoparticle derived from a self-assembled amphiphilic block-copolymer, they function with reduced activity as enzymatic substrates. |
| Databáze: | OpenAIRE |
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