An Easy Method for the N-Alkylation of Amides, Carbamates, Ureas and Azoles. Reactivity of 4-Chloromethylpyrazoles with Weak Nucleophiles under Neutral Conditions

Autor:	Mayoral Elena Perez, Ballesteros Paloma
Rok vydání:	2003
Předmět:	Pharmacology Character (mathematics) Nucleophile Group (periodic table) Chemistry Organic Chemistry Organic chemistry Molecule Reactivity (chemistry) General Medicine Alkylation Medicinal chemistry Analytical Chemistry
Zdroj:	ChemInform. 34
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200320133
Popis:	4-Chloromethylpyrazoles are shown to react readily with amides, carbamates, ureas and azoles under neutral conditions giving the corresponding N-monoalkylated derivatives with moderate yields. Alkylation of alcohols and thiols occurs under the same conditions. The procedure described may provide a convenient and easy method for the introduction of a 4-pyrazolylmethyl group into molecules containing functional groups with weak nucleophilic character.
Databáze:	OpenAIRE
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