Chronic Low-Calorie Sweetener Use and Risk of Abdominal Obesity among Older Adults: A Cohort Study
Autor: | David D. Liu, Luigi Ferrucci, Eleanor M. Simonsick, Toshiko Tanaka, Kristofer S. Gravenstein, Chee Wei Chia, Josephine M. Egan, Michelle Shardell |
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Jazyk: | angličtina |
Rok vydání: | 2016 |
Předmět: |
Male
Physiology lcsh:Medicine Weight Gain Biochemistry Body Mass Index Fats Endocrinology 0302 clinical medicine Risk Factors Medicine and Health Sciences Public and Occupational Health Mass index 030212 general & internal medicine lcsh:Science Abdominal obesity Multidisciplinary digestive oral and skin physiology Age Factors food and beverages Middle Aged Lipids Physiological Parameters Obesity Abdominal Female medicine.symptom Research Article Cohort study Adult medicine.medical_specialty Waist Endocrine Disorders 030209 endocrinology & metabolism 03 medical and health sciences Sex Factors Internal medicine Diabetes Mellitus medicine Humans Obesity Risk factor Nutrition Aged business.industry Body Weight lcsh:R Food Consumption Biology and Life Sciences Physical Activity Anthropometry medicine.disease Diet Metabolic Disorders Sweetening Agents lcsh:Q Physiological Processes Energy Intake business Body mass index Follow-Up Studies |
Zdroj: | PLoS ONE, Vol 11, Iss 11, p e0167241 (2016) PLoS ONE |
ISSN: | 1932-6203 |
Popis: | Introduction Low-calorie sweetener use for weight control has come under increasing scrutiny as obesity, especially abdominal obesity, remain entrenched despite substantial low-calorie sweetener use. We evaluated whether chronic low-calorie sweetener use is a risk factor for abdominal obesity. Participants and Methods We used 8268 anthropometric measurements and 3096 food diary records with detailed information on low-calorie sweetener consumption in all food products, from 1454 participants (741 men, 713 women) in the Baltimore Longitudinal Study of Aging collected from 1984 to 2012 with median follow-up of 10 years (range: 0–28 years). At baseline, 785 were low-calorie sweetener non-users (51.7% men) and 669 participants were low-calorie sweetener users (50.1% men). Time-varying low-calorie sweetener use was operationalized as the proportion of visits since baseline at which low-calorie sweetener use was reported. We used marginal structural models to determine the association between baseline and time-varying low-calorie sweetener use with longitudinal outcomes—body mass index, waist circumference, obesity and abdominal obesity—with outcome status assessed at the visit following low-calorie sweetener ascertainment to minimize the potential for reverse causality. All models were adjusted for year of visit, age, sex, age by sex interaction, race, current smoking status, dietary intake (caffeine, fructose, protein, carbohydrate, and fat), physical activity, diabetes status, and Dietary Approaches to Stop Hypertension score as confounders. Results With median follow-up of 10 years, low-calorie sweetener users had 0.80 kg/m2 higher body mass index (95% confidence interval [CI], 0.17–1.44), 2.6 cm larger waist circumference (95% CI, 0.71–4.39), 36.7% higher prevalence (prevalence ratio = 1.37; 95% CI, 1.10–1.69) and 53% higher incidence (hazard ratio = 1.53; 95% CI 1.10–2.12) of abdominal obesity than low-calorie sweetener non-users. Conclusions Low-calorie sweetener use is independently associated with heavier relative weight, a larger waist, and a higher prevalence and incidence of abdominal obesity suggesting that low-calorie sweetener use may not be an effective means of weight control. |
Databáze: | OpenAIRE |
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