Structural investigations on a linear isolated depsipeptide: the importance of dispersion interactions
| Autor: | Markus Gerhards, Anke Stamm, Dominic Bernhard |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Depsipeptide
Chemistry General Physics and Astronomy 02 engineering and technology Chromophore 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Hybrid functional Folding (chemistry) Computational chemistry Potential energy surface Peptide bond Physical and Theoretical Chemistry 0210 nano-technology Dispersion (chemistry) Basis set |
| Zdroj: | Physical Chemistry Chemical Physics. 18:15327-15336 |
| ISSN: | 1463-9084 1463-9076 |
| DOI: | 10.1039/c6cp01675h |
| Popis: | In this paper we present the first investigations on an isolated linear depsipetide CyCO-Gly-Lac-NH-PhOMe (cyclohexylcarbonyl-glycine-lactate-2-anisidine abbreviated as MOC) in a molecular beam experiment. Depsipeptides are a special subclass of peptides which contain at least one ester bond replacing a peptide bond. This leads to a different folding behavior and a different biological activity compared to a "normal" peptide. In order to analyze the folding of an isolated depsipeptide on a molecular level a variety of combined IR/UV methods including IR/IR/UV experiments are applied to MOC. Three different isomers are identified in combination with DFT calculations using the hybrid functional B3LYP-D3 with a TZVP basis set. The most stable structure shows a tweezer-like arrangement between the aromatic chromophore and the aliphatic cyclohexyl ring. A characteristic feature of this structure is that it is stabilized by dispersion interactions resulting from CH/π interactions. If dispersion is not taken into account this structural arrangement is no longer a minimum on the potential energy surface indicating the importance of dispersion interactions. |
| Databáze: | OpenAIRE |
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