Determination of Bitterness of Andrographis Herba Based on Electronic Tongue Technology and Discovery of the Key Compounds of Bitter Substances

Autor:	Zhiyong Li, Hongwei Wu, Zhuju Wang, Liying Tang, Xin Li, Hanyan Luo, Yaqi Lu, Xiao Zhang, Hongjun Yang, Xiankuo Yu
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	Taste food.ingredient Electronic tongue Andrographolide Pharmaceutical Science 02 engineering and technology electronic tongue Positive correlation 01 natural sciences Andrographis Herba Analytical Chemistry lcsh:QD241-441 chemistry.chemical_compound food lcsh:Organic chemistry Drug Discovery Spearman correlation analysis Physical and Theoretical Chemistry Mathematics Principal Component Analysis biology Traditional medicine 010405 organic chemistry Organic Chemistry chromatographic fingerprints 021001 nanoscience & nanotechnology biology.organism_classification 0104 chemical sciences Andrographis chemistry Chemistry (miscellaneous) Molecular Medicine 0210 nano-technology bitter substances Andrographis paniculata
Zdroj:	Molecules, Vol 23, Iss 12, p 3362 (2018) Molecules Volume 23 Issue 12
ISSN:	1420-3049
Popis:	Andrographis Herba (AH), the dry aerial segments of Andrographis paniculata (Burm.f.) Nees, is a common herbal remedy with bitter properties in traditional Chinese medicine (TCM) theory. Although bitterness is one of the features representing Chinese medicine, it has not been implemented as an index to assess the quality and efficacy of TCM because of peoples&rsquo subjectivity to taste. In this study, 30 batches of AH with different commercial classifications (leaves, stems, or mixtures of both) were collected. Bitterness of AH was quantified by electronic tongue technology. Meanwhile, chemical compositions were characterized through establishing high-performance liquid chromatography fingerprints. The result indicated that the radar curves of the bitterness from different AH commercial classifications displayed different taste fingerprint information. Based on six taste factors, a Principal Component Analysis (PCA) score three-dimensional (3D) plot exhibited a clear grouping trend (R2X, 0.912 Q2, 0.763) among the three different commercial classifications. Six compounds (Peaks 2, 3, 4, 6, 7, 8) with positive correlation to bitterness were discovered by a Spearman correlation analysis. Peaks 2, 6, 7, 8 were identified as andrographolide, neoandrographolide, 14-deoxyandrographolide, and dehydroandrographolide, respectively. The electronic tongue can be used to distinguish AH samples with different commercial classifications and for quality evaluation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eb680b1e233478739cfd791a1cc12d4 https://www.mdpi.com/1420-3049/23/12/3362 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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