Successful methylphenidate treatment of early onset extreme obesity in a child with a melanocortin-4 receptor gene mutation and attention deficit/hyperactivity disorder
| Autor: | Susann Scherag, Beate Albrecht, Anke Hinney, N. Barth, Johannes Hebebrand, Özgür Albayrak |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Medizin Gene mutation 03 medical and health sciences 0302 clinical medicine Melanocortin receptor Internal medicine medicine Humans Attention deficit hyperactivity disorder Obesity 030304 developmental biology 2. Zero hunger Pharmacology 0303 health sciences Methylphenidate medicine.disease 3. Good health Melanocortin 4 receptor Stimulant Endocrinology Attention Deficit Disorder with Hyperactivity Child Preschool Mutation Receptor Melanocortin Type 4 Melanocortin Psychology Body mass index 030217 neurology & neurosurgery medicine.drug |
| Popis: | We present the case report of a 2 year old boy with early onset extreme obesity (body mass index (BMI) 34.2 kg/m²; body mass index standard deviation score (BMI-SDS) 5.4) who is heterozygous for a non-conservative functionally relevant melanocortin MC 4 receptor mutation (Glu308Lys) and who also showed severe symptoms of attention deficit/hyperactivity disorder (ADHD). Treatment with the stimulant methylphenidate led to a sharp decrease of BMI to 21.8 kg/m² (BMI-SDS 2.8) within 24 months. We discuss potential mechanisms for this unusually large weight loss and suggest a potential link between the melanocortinergic and the dopaminergic systems, and the sympathetic nervous system. The potential benefit of methylphenidate in obese melanocortin MC 4 receptor mutation carriers with and without co-morbid ADHD warrants further studies. |
| Databáze: | OpenAIRE |
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