Cycloartane triterpenes from Beesia calthaefolia and their anticomplement structure–activity relationship study
| Autor: | Jing Zhang, Jin-Yuan Zhao, Li-Hua Mu, Ping Liu |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Stereochemistry Saponin Pharmaceutical Science Ranunculaceae 01 natural sciences Analytical Chemistry Terpene Structure-Activity Relationship 03 medical and health sciences chemistry.chemical_compound Triterpenoid Glucosides Drug Discovery Structure–activity relationship Moiety Organic chemistry Glycosyl Pharmacology chemistry.chemical_classification Complement Inactivator Proteins Beesia calthaefolia Molecular Structure biology Chemistry Organic Chemistry General Medicine Saponins biology.organism_classification Triterpenes 0104 chemical sciences 010404 medicinal & biomolecular chemistry 030104 developmental biology Complementary and alternative medicine Molecular Medicine Drugs Chinese Herbal |
| Zdroj: | Journal of Asian Natural Products Research. 18:1101-1107 |
| ISSN: | 1477-2213 1028-6020 |
| DOI: | 10.1080/10286020.2016.1174698 |
| Popis: | Fifteen cycloartane triterpenes were isolated from Beesia calthaefolia and among them one was new cycloartane triterpenoid. The structure of new compound was determined by the application of spectroscopic analyses and chemical methods. The fifteen compounds were evaluated for their anticomplement activity by classic pathway. The structure–activity relationship analysis indicated that the configurations of 12-OH is preferable to be α than β, and 18-OH can decrease while 15-OH can increase the anticomplement activity, but saponin with both 15-OH and 18-OH lost most of its activity. The glycosyl moiety of most isolated cycloartane triterpenes is xylosyl. When xylosyl was substituted by glucosyl or galactosyl, their anticomplement activities were decreased or increased, respectively. Further structure–activity relationship (SAR) studies must be carried out to achieve general conclusions regarding the effect of further functionalizations on the anticomplement saponins. |
| Databáze: | OpenAIRE |
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