COVID-19-Induced Anosmia and Ageusia Are Associated With Younger Age and Lower Blood Eosinophil Counts
| Autor: | Mali Barbi, Mohammad Asad, Ruth Eisenberg, Thomas J. Ow, Denise Sanchez Tejera, Mahendra Rangareddy, Alexandre Peshansky, Nadeem Akbar, Viraj V. Patel, Meaghan O’Neill, Danielle M. Bottalico, Valerie Fong, Avindra Nath, Bryan Smith, Mimi Y. Kim, Golda Hudes, Meryl Kravitz, Cynthia Matsumura, Denisa Ferastraoaru, Elina Jerschow, Merhunisa Karagic, Esha Sehanobish |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
2019-20 coronavirus outbreak Younger age Coronavirus disease 2019 (COVID-19) Anosmia Olfaction Disorders 03 medical and health sciences 0302 clinical medicine Disease severity medicine Humans Immunology and Allergy 030212 general & internal medicine 030223 otorhinolaryngology Blood eosinophil SARS-CoV-2 business.industry COVID-19 Infant Original Articles General Medicine Ageusia Eosinophil Eosinophils medicine.anatomical_structure Otorhinolaryngology Immunology medicine.symptom business |
| Zdroj: | Am J Rhinol Allergy |
| ISSN: | 1945-8932 1945-8924 |
| Popis: | Background Anosmia and ageusia are symptoms commonly associated with COVID-19, but the relationship with disease severity, onset and recovery are unclear. Objective To examine factors associated with anosmia and ageusia and the recovery from these symptoms in an ethnically diverse cohort. Methods Individuals tested for SARS-CoV-2 between March and April 2020 were eligible for the study. Randomly selected participants answered a telephone questionnaire on COVID-19 symptoms with a focus on anosmia and ageusia. Additionally, relevant past medical history and data on the COVID-19 clinical course were obtained from electronic medical records. 486 patients were in the COVID-19 group and 103 were COVID-19-negative. Results Patients who were younger were more likely to report anosmia and/or ageusia (odds ratio (OR) for anosmia per 1-year increase in age: 0·98, 95%CI:0–97-0·99, p = 0·003; for ageusia: 0·98, 95%CI:0·97-0·99, p = 0·005) as were patients with lower eosinophil counts (OR for anosmia per 0.1-K/μL increase in eosinophils: 0·02, 95%CI:0·001-0·46, p = 0·01, for ageusia 0·10, 95%CI:0·01-0·97, p = 0·047). Male gender was independently associated with a lower probability of ageusia (OR:0·56, 95%CI:0·38-0·82, p = 0·003) and earlier sense of taste recovery (HR:1·44, 95%CI:1·05-1·98, p = 0·02). Latinos showed earlier sense of taste recovery than white patients (HR:1·82, 95%CI:1·05-3·18, p = 0·03). Conclusion Anosmia and ageusia were more common among younger patients and those with lower blood eosinophil counts. Ageusia was less commonly reported among men, and time to taste recovery was earlier among both men and Latinos. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|