Ginkgo leaf extract and dipyridamole injection for chronic cor pulmonale: a PRISMA-compliant meta-analysis of randomized controlled trials
| Autor: | Yapei Yang, Hongmei Yue, Jian Qiu, Yijun Guo, Xin Xu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Hypertension Pulmonary Biophysics Plant Biology Traditional Chinese medicine chronic cor pulmonale Biochemistry law.invention 03 medical and health sciences traditional Chinese medicine 0302 clinical medicine Randomized controlled trial Pulmonary Heart Disease law Internal medicine medicine Humans 030212 general & internal medicine Adverse effect skin and connective tissue diseases Molecular Biology Research Articles Randomized Controlled Trials as Topic business.industry Plant Extracts Pharmacology & Toxicology Ginkgo leaf extract Ginkgo biloba Cell Biology Dipyridamole Dipyridamole injection meta-analysis Treatment Outcome Ginkgo leaf extract and dipyridamole injection Cardiovascular Diseases Cardiovascular System & Vascular Biology 030220 oncology & carcinogenesis Meta-analysis Chronic Disease business Adjuvant conventional treatments Systematic search Drugs Chinese Herbal |
| Zdroj: | Bioscience Reports |
| ISSN: | 1573-4935 |
| Popis: | Ginkgo leaf extract and dipyridamole injection (GLED), a kind of Chinese herbal medicine preparation, has been considered as a promising supplementary treatment for chronic cor pulmonale (CCP). Although an analysis of the published literature has been performed, the exact effects and safety of GLED have yet to be systematically investigated. Therefore, a wide-ranging systematic search of electronic databases from which to draw conclusions was conducted. All randomized controlled trials concerning the GLED plus conventional treatments for CCP were selected in the present study. Main outcomes were treatment efficacy, blood gas and hemorrheology indexes, and adverse events. Data from 28 trials with 2457 CCP patients were analyzed. The results indicated that, compared with conventional treatments alone, the combination of conventional treatments with GLED obviously improved the markedly effective rate (RR = 1.44, 95% CI = 1.31–1.58, P < 0.00001) and total effective rate (RR = 1.28, 95% CI = 1.18–1.38, P < 0.00001). Moreover, the hemorrheology (PaO2, P < 0.00001; PaCO2, P < 0.00001; SaO2, P < 0.00001; pH value, P = 0.05) and blood gas indexes (PV, WBHSV, WBMSV, WBLSV, hematocrit and FBG, P < 0.01) of CCP patients were also significantly ameliorated after the combined therapy. The frequency of adverse events did not differ significantly between the two groups (P > 0.05). In summary, evidence from the meta-analysis suggested that the combination of conventional treatments and GLED appeared to be effective and relatively safe for CCP. Therefore, GLED mediated therapy could be recommended as an adjuvant treatment for CCP. |
| Databáze: | OpenAIRE |
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