Effects of hypogonadism on brain development during adolescence in girls with Turner syndrome
| Autor: | Qiuling Zhao, Zhixin Zhang, Min Li, Sheng Xie, Chenxi Zhao, Xi-wei Liu, Gaolang Gong |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Adolescent medicine.drug_class Turner Syndrome Neuroimaging 050105 experimental psychology White matter 03 medical and health sciences 0302 clinical medicine Cognition Internal medicine Turner syndrome medicine Humans 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging Child X chromosome Research Articles Radiological and Ultrasound Technology Estradiol business.industry Hypogonadism 05 social sciences Genetic disorder Brain medicine.disease Magnetic Resonance Imaging White Matter Endocrinology medicine.anatomical_structure Neurology Estrogen Corticospinal tract Orbitofrontal cortex Female Neurology (clinical) Anatomy Follicle Stimulating Hormone Nerve Net business 030217 neurology & neurosurgery Hormone |
| Zdroj: | Hum Brain Mapp |
| Popis: | Gonadal steroids play an important role in brain development, particularly during puberty. Girls with Turner syndrome (TS), a genetic disorder characterized by the absence of all or part of the second X chromosome, mostly present a loss of ovarian function and estrogen deficiency, as well as neuroanatomical abnormalities. However, few studies have attempted to isolate the indirect effects of hormones from the direct genetic effects of X chromosome insufficiency. Brain structural (i.e., gray matter [GM] morphology and white matter [WM] connectivity) and functional phenotypes (i.e., resting-state functional measures) were investigated in 23 adolescent girls with TS using multimodal MRI to assess the role of hypogonadism in brain development in TS. Specifically, all girls with TS were divided into a hormonally subnormal group and an abnormal subgroup according to their serum follicle-stimulating hormone (FSH) levels, with the karyotypes approximately matched between the two groups. Statistical analyses revealed significant effects of the "group-by-age" interaction on GM volume around the left medial orbitofrontal cortex and WM diffusion parameters around the bilateral corticospinal tract, anterior thalamic radiation, left superior longitudinal fasciculus, and cingulum bundle, but no significant "group-by-age" or group differences were observed in resting-state functional measures. Based on these findings, estrogen deficiency has a nontrivial impact on the development of the brain structure during adolescence in girls with TS. Our present study provides novel insights into the mechanism by which hypogonadism influences brain development during adolescence in girls with TS, and highlights the important role of estrogen replacement therapy in treating TS. |
| Databáze: | OpenAIRE |
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