Preparation of Absorption-Resistant Hard Tissue Using Dental Pulp-Derived Cells and Honeycomb Tricalcium Phosphate

Autor:	Hidetsugu Tsujigiwa, Shan Qiusheng, Shigeko Fushimi, Shintaro Sukegawa, Yasunori Inada, Kiyofumi Takabatake, Hotaka Kawai, Hitoshi Nagatsuka, Keisuke Nakano
Rok vydání:	2021
Předmět:	Technology 0206 medical engineering honeycomb TCP 02 engineering and technology Absorption (skin) osteodentin Bone tissue Article dentin formation stomatognathic system Osteoclast In vivo Dental pulp stem cells medicine Dentin General Materials Science Microscopy QC120-168.85 mesenchymal stem cells Chemistry Regeneration (biology) QH201-278.5 Mesenchymal stem cell Engineering (General). Civil engineering (General) 021001 nanoscience & nanotechnology 020601 biomedical engineering TK1-9971 stomatognathic diseases medicine.anatomical_structure Descriptive and experimental mechanics Electrical engineering. Electronics. Nuclear engineering TA1-2040 dental pulp 0210 nano-technology matrix formation Biomedical engineering
Zdroj:	Materials Volume 14 Issue 12 Materials, Vol 14, Iss 3409, p 3409 (2021)
ISSN:	1996-1944
Popis:	In recent years, there has been increasing interest in the treatment of bone defects using undifferentiated mesenchymal stem cells (MSCs) in vivo. Recently, dental pulp has been proposed as a promising source of pluripotent mesenchymal stem cells (MSCs), which can be used in various clinical applications. Dentin is the hard tissue that makes up teeth, and has the same composition and strength as bone. However, unlike bone, dentin is usually not remodeled under physiological conditions. Here, we generated odontoblast-like cells from mouse dental pulp stem cells and combined them with honeycomb tricalcium phosphate (TCP) with a 300 μm hole to create bone-like tissue under the skin of mice. The bone-like hard tissue produced in this study was different from bone tissue, i.e., was not resorbed by osteoclasts and was less easily absorbed than the bone tissue. It has been suggested that hard tissue-forming cells induced from dental pulp do not have the ability to induce osteoclast differentiation. Therefore, the newly created bone-like hard tissue has high potential for absorption-resistant hard tissue repair and regeneration procedures.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eaae80652dedbaf29c872bec0ea2e7a https://pubmed.ncbi.nlm.nih.gov/34202970 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.