Preparation, Drug Releasing Property and Pharmacodynamics of Soy Isoflavone-Loaded Chitosan Microspheres
| Autor: | Chenyun Huang, Zhongyan Du, Jiazhen Zhu, Minhua Dou, Chunlei Fan, Linfeng Hu, Xiaobing Dou, Ying Qian, Jia Gao |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Alginates
lcsh:Medicine Antioxidants Chitosan chemistry.chemical_compound Mice Glucuronic Acid Blood plasma Animals Particle Size lcsh:Science Drug Carriers Multidisciplinary Chromatography Behavior Animal business.industry Hexuronic Acids lcsh:R Metabolism Isoflavones Glucuronic acid Microspheres Biotechnology chemistry Pharmacodynamics Delayed-Action Preparations lcsh:Q Female Particle size Rabbits Soybeans Drug carrier business Research Article |
| Zdroj: | PLoS ONE PLoS ONE, Vol 8, Iss 11, p e79698 (2013) |
| ISSN: | 1932-6203 |
| Popis: | Soybean isoflavone (SIF) has anti-aging properties and many other biological functions; however, SIF is difficult to reach higher blood concentration due to its rapid metabolism. Therefore, it is of great value to design and produce a sustained-release formulation that is able to maintain a stable level of plasma concentrations. In this paper, soybean isoflavone sustained-release microsphere from chitosan and sodium alginate was prepared successfully. The important factors that determined the quality of the microspheres were the sodium alginate concentration in solution B, the ratio of soybean isoflavone to chitosan and the mixing speed. The relative yield, encapsulation efficiency and drug loading capability of SIF were much higher than the existing commercial formulations. In real gastrointestinal conditions, compared with the non-sustained release group, the release rate of SIF slowed down and the reaction time was prolonged. Animal experiments showed that sustained-release microspheres intensified the anti-aging potentials of SIF. Compared with the Non-sustained release (NSR) group mice, oral SIF/CHI microsphere treated mice were better in the Morris Water Maze Test (MWMT), the MDA level in the both plasma and brain of the sustained release (SR) group mice decreased, and SOD content was remarkably improved. |
| Databáze: | OpenAIRE |
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