Reaction time slowing in HIV-1-infected individuals: Role of the preparatory interval

Autor: E. D. Nannis, W. A. Law, L. R. Temoshok, R. L. Mapou, T. L. Roller, Alex Martin
Rok vydání: 1995
Předmět:
Zdroj: Journal of Clinical and Experimental Neuropsychology. 17:122-133
ISSN: 1744-411X
1380-3395
DOI: 10.1080/13803399508406587
Popis: Psychomotor speed and directed attention were evaluated in 83 human immunodeficiency virus-1-infected individuals (HIV+) and 50 HIV-1 seronegative (HIV-) control participants using simple and choice reaction time (RT) tasks. The simple RT task included 1- and 3-s, irregularly varied preparatory intervals (PI) between the warning and target lights. Relative to the HIV-group, simple and choice RT were significantly slowed in the HIV+ group. Further, again relative to the HIV- controls, the HIV+ group did not show expected faster RT with increased response preparation time in the simple RT task. This also occurred in some HIV+ subjects who did not have psychomotor slowing. These findings suggest that RT performance in HIV-1-infected individuals may reflect separate processes associated with psychomotor slowing and impaired ability to direct attention. Possible neural mechanisms associated with control of these processes are discussed.
Databáze: OpenAIRE