Release of Proteolytic Enzyme from Cat Brain During Stimulation
| Autor: | David Symmes, Alexandre Corrado, Loring F. Chapman, Virgilio Fortes, Armando O. Ramos |
|---|---|
| Rok vydání: | 1960 |
| Předmět: |
Proteases
Globulin biology Chemistry Central nervous system Proteolytic enzymes Brain Stimulation Protein catabolism medicine.anatomical_structure Cerebrospinal fluid Arts and Humanities (miscellaneous) Biochemistry Cats biology.protein medicine Animals Nervous System Physiological Phenomena Denaturation (biochemistry) Neurology (clinical) Peptide Hydrolases |
| Zdroj: | Archives of Neurology. 3:43-45 |
| ISSN: | 0003-9942 |
| DOI: | 10.1001/archneur.1960.00450010043004 |
| Popis: | Introduction Reversible chemical changes in rapidly frozen homogenate have been described by other investigators which indicate that stimulation of the brain, either directly or indirectly through afferent nerves, induces a state of excitation in which the rate of protein breakdown increases, proteolytic enzymes are activated, and partial protein denaturation occurs; with intense and prolonged stimulation the denaturation may be irreversible. 1-3 The observation that certain proteolytic enzymes when incubated with plasma globulin form polypeptides 4,5 that can be assayed readily in minute amounts, offers a method for observing small increases of proteolytic enzymes in dilute solutions such as perfusate collected before and during excitation. A vasodilator polypeptide formed by the action of a proteolytic enzyme on plasma globulin has been shown to be an important mediator of local vasomotor control in the salivary gland. 6 Also, human cerebrospinal fluid collected from patients with disorders of the central nervous system forms |
| Databáze: | OpenAIRE |
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