Roles of Krüppel‐like factor 5 in kidney disease
Autor: | Jia Li, Lu Cai, Zhonggao Xu, Wenqian Zhou, Madhavi J. Rane, Liang Liu |
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Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
kidney disease Kruppel-Like Transcription Factors Reviews Apoptosis Kruppel-like factors Review Disease Bioinformatics Pathogenesis 03 medical and health sciences 0302 clinical medicine Fibrosis medicine Renal fibrosis Animals Humans Gene Regulatory Networks RNA Processing Post-Transcriptional Transcription factor Krüppel‐like factor 5 Krüppel‐like factors Cell Proliferation Kidney diabetes business.industry fibrosis Cell Biology medicine.disease Disease Models Animal 030104 developmental biology medicine.anatomical_structure Gene Expression Regulation inflammation 030220 oncology & carcinogenesis Molecular Medicine Kidney Diseases Disease Susceptibility business Protein Processing Post-Translational Biomarkers Signal Transduction Kidney disease |
Zdroj: | Journal of Cellular and Molecular Medicine |
ISSN: | 1582-4934 1582-1838 |
Popis: | Transcription factor Krüppel‐like factor 5 (KLF5) is a member of the Krüppel‐like factors’ (KLFs) family. KLF5 regulates a number of cellular functions, such as apoptosis, proliferation and differentiation. Therefore, KLF5 can play a role in many diseases, including, cancer, cardiovascular disease and gastrointestinal disorders. An important role for KLF5 in the kidney was recently reported, such that KLF5 regulated podocyte apoptosis, renal cell proliferation, tubulointerstitial inflammation and renal fibrosis. In this review, we have summarized the available information in the literature with a brief description on how transcriptional, post‐transcriptional and post‐translational modifications of KLF5 modulate its function in a variety of organs including the kidney with a focus of its importance on the pathogenesis of various kidney diseases. Furthermore, we also have outlined the current and possible mechanisms of KLF5 activation in kidney diseases. These studies suggest a need for more systemic investigations, particularly for generation of animal models with renal cell‐specific deletion or overexpression of KLF5 gene to examine direct contributions of KLF5 to various kidney diseases. This will promote further experimentation in the development of therapies to prevent or treat various kidney diseases. |
Databáze: | OpenAIRE |
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