Immunohistochemical evidence for human immunodeficiency virus-1 infection of liver kupffer cells
| Autor: | Christian Bréchot, C. Housset, Marche C, O. Boucher, Pierre-Marie Girard, J. Leibowitch, Saimot Ag |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Kupffer Cells Liver cytology medicine.drug_class HIV Core Protein p24 Gene Products gag HIV Infections Monoclonal antibody Virus Pathology and Forensic Medicine AIDS-Related Complex medicine Humans Protein Precursors Acquired Immunodeficiency Syndrome Immunoperoxidase biology Viral Core Proteins Kupffer cell Antibodies Monoclonal Middle Aged medicine.disease Immunohistochemistry medicine.anatomical_structure Granuloma Immunology HIV-1 biology.protein Female Antibody |
| Zdroj: | Human Pathology. 21:404-408 |
| ISSN: | 0046-8177 |
| DOI: | 10.1016/0046-8177(90)90202-g |
| Popis: | To investigate the possibility of human immunodeficiency virus-(HIV) 1 infection of liver cells, liver samples from 17 patients with either acquired immunodeficiency syndrome (AIDS, 13), AIDS-related complex (ARC, 3), or lymphadenopathy syndrome (LAS, 1) were studied. A monoclonal antibody directed against the p24 gag HIV-1 protein was used in an immunoperoxidase assay and yielded positive results in seven out of 17 samples. Staining by anti-p24 antibody was of three types: diffuse in Kupffer cells of most samples, inside granuloma in cells that were probably histiocytes, and in some sinusoidal cells whose origin was difficult to ascertain. Attempts to locate the CD4 membrane antigen showed that it was mainly present on endothelial sinusoidal cells. These results indicate that liver cells, including Kupffer cells, might be infected by HIV-1, and that these cells might be involved in certain liver lesions observed during HIV-1 infection, particularly sinusoidal abnormalities. |
| Databáze: | OpenAIRE |
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