Associations between urinary iodine concentration, lipid profile and other cardiometabolic risk factors in adolescents: a cross-sectional, population-based analysis
| Autor: | Lina Zhang, Lixin Guo, Li Liu, Jie Zhang, Tongzhang Xian, Xiaoxia Wang, Liang Sun, Dongni Yu, Fuli Man, Xianbo Zhang, Xiaofan Jia, Qi Pan, Qi Zhou |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Adolescent National Health and Nutrition Examination Survey Apolipoprotein B Nutritional Status Medicine (miscellaneous) 030209 endocrinology & metabolism Logistic regression Metabolic equivalent Young Adult 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine medicine Humans 030212 general & internal medicine Risk factor Child Dyslipidemias Nutrition and Dietetics medicine.diagnostic_test biology business.industry Nutrition Surveys Lipids Physical activity level Cross-Sectional Studies Logistic Models Cardiovascular Diseases biology.protein Female Urinary iodine Lipid profile business Biomarkers Iodine |
| Zdroj: | British Journal of Nutrition. 121:1039-1048 |
| ISSN: | 1475-2662 0007-1145 |
| Popis: | Low urinary iodine concentration (UIC) is associated with dyslipidaemia in adults but is not well characterised in adolescents. Because dyslipidaemia is a cardiovascular risk factor, identifying such an association in adolescents would allow for the prescription of appropriate measures to maintain cardiovascular health. The present study addresses this question using data in the 2001–2012 National Health and Nutrition Examination Survey for 1692 adolescents aged 12–19 years. Primary outcomes were UIC, cardiometabolic risk factors and dyslipidaemia. Data for subjects categorised by low and normal UIC and by sex were analysed by univariate and multivariate logistic regression. Treating UIC as the independent variable, physical activity level, apoB and lipid profiles differed significantly between subjects with low and normal UIC. Subjects with low UIC had a significantly greater risk of elevated total cholesterol (TC) (95 % CI 1·37, 2·81), elevated non-HDL (95 % CI 1·33, 2·76) and elevated LDL (95 % CI 1·83, 4·19) compared with those with normal UIC. Treating UIC as a dependent variable, the risk of low UIC was significantly greater in those with higher apoB (95 % CI 1·52, 19·08), elevated TC (≥4·4mmol/l) (95 % CI 1·37, 2·81) and elevated non-HDL (≥3·11mmol/l) (95 % CI 1·33, 2·76) than in those with normal UIC. These results show that male and female adolescents with low UIC tend to be at greater risk of dyslipidaemia and abnormal cardiometabolic biomarkers, though the specific abnormal parameters differed between sexes. These results may help to identify youth who would benefit from interventions to improve their cardiometabolic risk. |
| Databáze: | OpenAIRE |
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