Larynx preservation protocols: long-term functional outcomes in good responders to induction chemotherapy for pyriform sinus carcinoma
| Autor: | Anne-Marie Le Ridant, Pavel Dulguerov, Zacharias Vourexakis, François Janot |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Laryngectomy Tracheotomy Swallowing otorhinolaryngologic diseases Carcinoma Medicine Humans Aged Hypopharyngeal Neoplasms business.industry Induction chemotherapy Chemoradiotherapy Adjuvant Induction Chemotherapy Middle Aged medicine.disease Combined Modality Therapy ddc:616.8 Surgery Deglutition stomatognathic diseases Pyriform Sinus Treatment Outcome Otorhinolaryngology Concomitant Carcinoma Squamous Cell Voice Female France Larynx Neoplasm Recurrence Local business Chemoradiotherapy |
| Zdroj: | ORL, Vol. 76, No 3 (2014) pp. 165-70 |
| ISSN: | 1423-0275 0301-1569 |
| Popis: | Background/Aims: Larynx preservation for laryngopharyngeal carcinomas aims to avoid the mutilation of a total laryngectomy without compromising survival or functionality. The aim of the present study on pyriform sinus squamous cell carcinoma (SCC) is to evaluate the long-term functional outcomes of larynx preservation in good responders to induction chemotherapy (ICT). Methods: The study was carried out in a tertiary referral cancer center in France. The subjects were good responders to ICT for pyriform sinus SCC, subsequently treated with adjuvant radiation therapy (RT) - with or without concomitant chemotherapy - between 1999 and 2008. Only patients without recurrence at 3 years were included. The evaluated pharyngolaryngeal functions were airway patency, oral communication and oral feeding, based on a self-administered questionnaire and the patients' medical records. Results: Twenty-eight patients were retained. Two (7%) patients needed a tracheotomy during or after the treatment and 2 (7%) had total laryngectomy for a late local recurrence. At least 3 years after the end of treatment, all patients were exclusively fed by mouth. All the evaluated patients judged their voice performance as ‘adequate for everyday oral communication'. Conclusions: In the long run, patients with pyriform sinus SCC who are candidates for larynx preservation and respond favorably to ICT present a satisfactory functional outcome when treated with adjuvant RT. |
| Databáze: | OpenAIRE |
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