Lesson of the month 1: A rare adverse reaction between flucloxacillin and paracetamol
| Autor: | Aneeka Chavda, George D. Katritsis, William Osborne, Jon S. Friedland |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Drug-Related Side Effects and Adverse Reactions medicine.drug_class Antibiotics Anion gap 030204 cardiovascular system & hematology Floxacillin 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans 030212 general & internal medicine Adverse effect Lesson of the Month Acidosis Acetaminophen business.industry Metabolic acidosis General Medicine Drug interaction medicine.disease Flucloxacillin medicine.symptom business Adverse drug reaction medicine.drug |
| ISSN: | 1473-4893 |
| Popis: | Flucloxacillin, a beta-lactam antibiotic, is a commonly prescribed antibiotic for the treatment of infections caused by staphylococci and streptococci, most notably Staphylococcus aureus. Paracetamol is one of the most dispensed medications by NHS England and is used for the treatment of fever and pain.(1) However most doctors are unaware that concurrent use of these drugs can cause a potentially fatal drug interaction due to pyroglutamic acidosis (PGA), also known as 5-oxoprolinaemia. PGA is a rare cause of raised anion gap metabolic acidosis due to disruption of the γ-glutamyl cycle. We report the case of a patient with multiple comorbidities who developed PGA due to coadministration of paracetamol and flucloxacillin. |
| Databáze: | OpenAIRE |
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