A Review on Recent Advances in Aloperine Research: Pharmacological Activities and Underlying Biological Mechanisms
| Autor: | Desheng Hu, Fei Sun, Haifeng Zhou, Heng Fan, Mingyue Li, Faxi Wang, Yalan Dong, Junyi Li |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Pharmacology biological mechanisms Sophora biology traditional herbal medicine lcsh:RM1-950 pharmacological effects Sophora genus phytomedicine aloperine Review biology.organism_classification 03 medical and health sciences 030104 developmental biology 0302 clinical medicine lcsh:Therapeutics. Pharmacology 030220 oncology & carcinogenesis Pharmacology (medical) Neuroscience Sophora alopecuroides |
| Zdroj: | Frontiers in Pharmacology, Vol 11 (2020) Frontiers in Pharmacology |
| ISSN: | 1663-9812 |
| DOI: | 10.3389/fphar.2020.538137/full |
| Popis: | Aloperine, a quinolizidine-type alkaloid, was first isolated from the seeds and leaves of herbal plant, Sophora alopecuroides L. Empirically, Sophora alopecuroides L. is appreciated for its anti-dysentry effect, a property that is commonly observed in other Sophora Genus phytomedicines. Following the rationale of reductionism, subsequent biochemical analyses attribute such anti-dysentry effect to the bactericidal activity of aloperine. From then on, the multiple roles of aloperine are gradually revealed. Accumulating evidence suggests that aloperine possesses multiple pharmacological activities and holds a promising potential in clinical conditions including skin hyper-sensitivity, tumor and inflammatory disorders etc.; however, the current knowledge on aloperine is interspersed and needs to be summarized. To facilitate further investigation, herein, we conclude the key pharmacological functions of aloperine, and most importantly, the underlying cellular and molecular mechanisms are clarified in detail to explain the functional mode of aloperine. |
| Databáze: | OpenAIRE |
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