Multimodal Imaging and Detection Strategy With 124 I-Labeled Chimeric Monoclonal Antibody cG250 for Accurate Localization and Confirmation of Extent of Disease During Laparoscopic and Open Surgical Resection of Clear Cell Renal Cell Carcinoma
| Autor: | Michael V. Knopp, Robert R. Bahnson, Charles L. Hitchcock, Nathan Hall, Eamonn E. Bahnson, Edward W. Martin, Cathy Mojzisik, Douglas A Murrey, Stephen P. Povoski, David Sharp |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty image-guided surgery medicine.medical_treatment Multimodal Imaging Nephrectomy Iodine Radioisotopes surgical oncology Monoclonal antibody G250 Surgical oncology Renal cell carcinoma Humans Medicine urology Laparoscopy Carcinoma Renal Cell medicine.diagnostic_test business.industry Antibodies Monoclonal Original Articles Middle Aged medicine.disease Kidney Neoplasms Clear cell renal cell carcinoma Image-guided surgery Surgery Computer-Assisted Positron-Emission Tomography Female Surgery Radiology Tomography X-Ray Computed business Clear cell |
| Zdroj: | Surgical Innovation |
| ISSN: | 1553-3514 1553-3506 |
| Popis: | Renal cell carcinoma (RCC) accounts for approximately 85% to 90% of all primary kidney malignancies, with clear cell RCC (ccRCC) constituting approximately 70% to 85% of all RCCs. This study describes an innovative multimodal imaging and detection strategy that uses 124I-labeled chimeric monoclonal antibody G250 (124I-cG250) for accurate preoperative and intraoperative localization and confirmation of extent of disease for both laparoscopic and open surgical resection of ccRCC. Two cases presented herein highlight how this technology can potentially guide complete surgical resection and confirm complete removal of all diseased tissues. This innovative 124I-cG250 (ie, 124I-girentuximab) multimodal imaging and detection approach, which would be clinically very useful to urologic surgeons, urologic medical oncologists, nuclear medicine physicians, radiologists, and pathologists who are involved in the care of ccRCC patients, holds great potential for improving the diagnostic accuracy, operative planning and approach, verification of disease resection, and monitoring for evidence of disease recurrence in ccRCC patients. |
| Databáze: | OpenAIRE |
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