Comparative analysis of the long-term effect of two families of high-flux polysulfone dialysers on platelet count: a retrospective cross-sectional study
| Autor: | Rosaria Del Giorno, Giorgia Bianchi, Lorenzo Berwert, Silvio Pianca, Luca Gabutti, Olivier Giannini |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
comparative analysis Therapeutics and Clinical Risk Management Cross-sectional study medicine.medical_treatment 030232 urology & nephrology thrombocytopenia 030204 cardiovascular system & hematology Logistic regression Gastroenterology polysulfone membranes retrospective pilot study 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Pharmacology (medical) Term effect Platelet General Pharmacology Toxicology and Pharmaceutics Prospective cohort study Original Research Chemical Health and Safety business.industry Retrospective cohort study General Medicine platelet count Hemodialysis Complication business Safety Research |
| Zdroj: | Therapeutics and Clinical Risk Management |
| ISSN: | 1178-203X 1176-6336 |
| Popis: | Rosaria Del Giorno,1 Lorenzo Berwert,1 Silvio Pianca,2 Giorgia Bianchi,3 Olivier Giannini,4 Luca Gabutti1 1Department of Internal Medicine, Nephrology and Dialysis Unit, Regional Hospital of Bellinzona and Valli, Ente Ospedaliero Cantonale, Bellinzona, 2Nephrology Unit, Civico Hospital, Ente Ospedaliero Cantonale, Lugano, 3Nephrology Unit, La Carità Hospital, Ente Ospedaliero Cantonale, Locarno, 4Nephrology Unit, Beata Vergine Hospital, Ente Ospedaliero Cantonale, Mendrisio, Switzerland Introduction: Thrombocytopenia is a potential complication of hemodialysis (HD), and its occurrence has been described even with highly biocompatible polysulfone (PSf) membranes. Dialysis units routinely monitor platelet (PLT) count at the beginning of HD sessions. However, considering that the long-term effects on PLT count could easily be missed, the prevalence of HD-related thrombocytopenia could be underestimated. In the present study, we aimed to investigate the following: 1) the long-term impact of HD treatment on PLT count, comparing two families of dialysis membranes made up of similar PSfs; 2) whether the switch between the dialysis membranes studied significantly affects PLT count; and 3) the prevalence and the risk of HD-induced thrombocytopenia according to the dialysis membranes used. Methods: A cross-sectional retrospective study was performed comprising 157 adult chronic HD patients. The HD membranes under investigation were of the series FX, Helixone® Fresenius (Filters A), and Polyflux® Gambro (Filters B). Patients were treated in 4 dialysis units in Southern Switzerland. Data were collected from a centralized computing platform. Findings: PLT count significantly differs between Filters A and B with, respectively, 188 (153–243) ×10E9/L versus 214 (179–255) ×10E9/L (p=0.036). The prevalence of thrombocytopenia was higher for Filter A compared with Filter B (28.4% versus 12.8%; p |
| Databáze: | OpenAIRE |
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