Single Nucleotide Polymorphisms within Interferon Signaling Pathway Genes Are Associated with Colorectal Cancer Susceptibility and Survival

Autor: Asta Försti, Shun Lu, Veronika Vymetalkova, Alessio Naccarati, Bowang Cheng, Ludmila Vodickova, Barbara Pardini, Kari Hemminki, Thomas Buchler, Stefanie Huhn, Pavel Vodicka
Rok vydání: 2014
Předmět:
Male
Oncology
Epidemiology
Colorectal cancer
lcsh:Medicine
Bioinformatics
Linkage Disequilibrium
Risk Factors
Gastrointestinal Cancers
Medicine and Health Sciences
lcsh:Science
Multidisciplinary
Cancer Risk Factors
Hazard ratio
Public Health
Global Health
Social Medicine and Epidemiology
Middle Aged
Hospitals
Genetic Epidemiology
Female
Colorectal Neoplasms
Cancer Epidemiology
Research Article
Signal Transduction
medicine.medical_specialty
Genotype
Genetic Causes of Cancer
Single-nucleotide polymorphism
Gastroenterology and Hepatology
Biology
Polymorphism
Single Nucleotide
Disease-Free Survival
Internal medicine
medicine
Humans
Genetic Predisposition to Disease
Aged
Proportional Hazards Models
Proportional hazards model
lcsh:R
medicine.disease
Biomarker Epidemiology
Case-Control Studies
Multivariate Analysis
IRF7
IFNK
lcsh:Q
Interferons
IRF5
Interferon regulatory factors
Zdroj: PLoS ONE
PLoS ONE, Vol 9, Iss 10, p e111061 (2014)
PLoS ONE; 9(10), no e111061 (2014)
ISSN: 1932-6203
Popis: Interferon (IFN) signaling has been suggested to play an important role in colorectal carcinogenesis. Our study aimed to examine potentially functional genetic variants in interferon regulatory factor 3 (IRF3), IRF5, IRF7, type I and type II IFN and their receptor genes with respect to colorectal cancer (CRC) risk and clinical outcome. Altogether 74 single nucleotide polymorphisms (SNPs) were covered by the 34 SNPs genotyped in a hospital-based case-control study of 1327 CRC cases and 758 healthy controls from the Czech Republic. We also analyzed these SNPs in relation to overall survival and event-free survival in a subgroup of 483 patients. Seven SNPs in IFNA1, IFNA13, IFNA21, IFNK, IFNAR1 and IFNGR1 were associated with CRC risk. After multiple testing correction, the associations with the SNPs rs2856968 (IFNAR1) and rs2234711 (IFNGR1) remained formally significant (P = 0.0015 and P
Databáze: OpenAIRE
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