Single Nucleotide Polymorphisms within Interferon Signaling Pathway Genes Are Associated with Colorectal Cancer Susceptibility and Survival
Autor: | Asta Försti, Shun Lu, Veronika Vymetalkova, Alessio Naccarati, Bowang Cheng, Ludmila Vodickova, Barbara Pardini, Kari Hemminki, Thomas Buchler, Stefanie Huhn, Pavel Vodicka |
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Rok vydání: | 2014 |
Předmět: |
Male
Oncology Epidemiology Colorectal cancer lcsh:Medicine Bioinformatics Linkage Disequilibrium Risk Factors Gastrointestinal Cancers Medicine and Health Sciences lcsh:Science Multidisciplinary Cancer Risk Factors Hazard ratio Public Health Global Health Social Medicine and Epidemiology Middle Aged Hospitals Genetic Epidemiology Female Colorectal Neoplasms Cancer Epidemiology Research Article Signal Transduction medicine.medical_specialty Genotype Genetic Causes of Cancer Single-nucleotide polymorphism Gastroenterology and Hepatology Biology Polymorphism Single Nucleotide Disease-Free Survival Internal medicine medicine Humans Genetic Predisposition to Disease Aged Proportional Hazards Models Proportional hazards model lcsh:R medicine.disease Biomarker Epidemiology Case-Control Studies Multivariate Analysis IRF7 IFNK lcsh:Q Interferons IRF5 Interferon regulatory factors |
Zdroj: | PLoS ONE PLoS ONE, Vol 9, Iss 10, p e111061 (2014) PLoS ONE; 9(10), no e111061 (2014) |
ISSN: | 1932-6203 |
Popis: | Interferon (IFN) signaling has been suggested to play an important role in colorectal carcinogenesis. Our study aimed to examine potentially functional genetic variants in interferon regulatory factor 3 (IRF3), IRF5, IRF7, type I and type II IFN and their receptor genes with respect to colorectal cancer (CRC) risk and clinical outcome. Altogether 74 single nucleotide polymorphisms (SNPs) were covered by the 34 SNPs genotyped in a hospital-based case-control study of 1327 CRC cases and 758 healthy controls from the Czech Republic. We also analyzed these SNPs in relation to overall survival and event-free survival in a subgroup of 483 patients. Seven SNPs in IFNA1, IFNA13, IFNA21, IFNK, IFNAR1 and IFNGR1 were associated with CRC risk. After multiple testing correction, the associations with the SNPs rs2856968 (IFNAR1) and rs2234711 (IFNGR1) remained formally significant (P = 0.0015 and P |
Databáze: | OpenAIRE |
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