Safety Study of Transcranial Static Magnetic Field Stimulation (tSMS) of the Human Cortex

Autor: Vanesa Soto-León, José Abad-Rodríguez, Alonso M. Higuero, Yolanda A. Pérez-Borrego, M.C. Carrasco-Lopez, Javier J. Gonzalez-Rosa, Michela Campolo, Bryan A. Strange, Antonio Oliviero, Guglielmo Foffani
Rok vydání: 2014
Předmět:
Adult
Male
Medicina
Biophysics
Stimulation
Neuropsychological Tests
lcsh:RC321-571
03 medical and health sciences
Magnetics
Young Adult
0302 clinical medicine
Cognition
Neuronal damage
Repetitive transcranial magnetic stimulation (rTMS)
Humans
Attention
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
030304 developmental biology
Cerebral Cortex
Telecomunicaciones
0303 health sciences
NIBS
Verbal Behavior
General Neuroscience
S100 Proteins
Healthy subjects
Tissue level
Middle Aged
Transcranial Magnetic Stimulation
3. Good health
Cognitive Alteration
Cortex (botany)
Phosphopyruvate Hydratase
Female
Neurology (clinical)
Safety
Transcranial static magnetic field stimulation (tSMS)
Neuron-specific enolase
Psychology
Neuroscience
030217 neurology & neurosurgery
Psychomotor Performance
S100
Zdroj: Brain Stimulation, ISSN 1935-861X, 2015-05, Vol. 8, No. 3
Archivo Digital UPM
Universidad Politécnica de Madrid
Brain Stimulation, Vol 8, Iss 3, Pp 481-485 (2015)
ISSN: 1876-4754
Popis: Background Transcranial static magnetic field stimulation (tSMS) in humans reduces cortical excitability. Objective The objective of this study was to determine if prolonged tSMS (2 h) could be delivered safely in humans. Safety limits for this technique have not been described. Methods tSMS was applied for 2 h with a cylindric magnet on the occiput of 17 healthy subjects. We assessed tSMS-related safety aspects at tissue level by measuring levels of neuron-specific enolase (NSE, a marker of neuronal damage) and S100 (a marker of glial reactivity and damage). We also included an evaluation of cognitive side effects by using a battery of visuomotor and cognitive tests. Results tSMS did not induce any significant increase in NSE or S100. No cognitive alteration was detected. Conclusions Our data indicate that the application of tSMS is safe in healthy human subjects, at least within these parameters.
Databáze: OpenAIRE
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