Experimental Zika Virus Infection in the Pregnant Common Marmoset Induces Spontaneous Fetal Loss and Neurodevelopmental Abnormalities
| Autor: | Suzette D. Tardif, Claudia Sanchez San Martin, Jean L. Patterson, Luis D. Giavedoni, Vida L. Hodara, Melissa J. Suter, Kjersti Aagaard, Manasi Tamhankar, Tony Li, Eumenia Costa da Cunha Castro, Laura M. Parodi, Donna Layne-Colon, Charles Y. Chiu, Calla Martyn, Shigeo Yagi, Maxim Seferovic, Julienne N. Rutherford, Kevin Reyes |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Placenta lcsh:Medicine Disease Reproductive health and childbirth Virus Replication Zika virus Pathogenesis 0302 clinical medicine Pregnancy 2.1 Biological and endogenous factors 2.2 Factors relating to the physical environment 030212 general & internal medicine Aetiology lcsh:Science Pediatric 0303 health sciences Multidisciplinary biology Zika Virus Infection Infectious Marmoset Callithrix 3. Good health medicine.anatomical_structure Infectious Diseases Interferon Type I Embryo Loss Cytokines Female Infection Viremia Gestational Age Nervous System Malformations Article 03 medical and health sciences Interferon-gamma Fetus biology.animal medicine Animals Humans Conditions Affecting the Embryonic and Fetal Periods Seroconversion 030304 developmental biology business.industry Animal Spontaneous lcsh:R Abortion Zika Virus Perinatal Period - Conditions Originating in Perinatal Period medicine.disease biology.organism_classification Pregnancy Complications 030104 developmental biology Good Health and Well Being Immunology Disease Models lcsh:Q business |
| Zdroj: | Scientific Reports Scientific reports, vol 8, iss 1 Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018) |
| ISSN: | 2045-2322 |
| Popis: | During its most recent outbreak across the Americas, Zika virus (ZIKV) was surprisingly shown to cause fetal loss and congenital malformations in acutely and chronically infected pregnant women. However, understanding the underlying pathogenesis of ZIKV congenital disease has been hampered by a lack of relevant in vivo experimental models. Here we present a candidate New World monkey model of ZIKV infection in pregnant marmosets that faithfully recapitulates human disease. ZIKV inoculation at the human-equivalent of early gestation caused an asymptomatic seroconversion, induction of type I/II interferon-associated genes and proinflammatory cytokines, and persistent viremia and viruria. Spontaneous pregnancy loss was observed 16–18 days post-infection, with extensive active placental viral replication and fetal neurocellular disorganization similar to that seen in humans. These findings underscore the key role of the placenta as a conduit for fetal infection, and demonstrate the utility of marmosets as a highly relevant model for studying congenital ZIKV disease and pregnancy loss. |
| Databáze: | OpenAIRE |
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