GABAA Receptor-Mediated Sleep-Promoting Effect of Saaz–Saphir Hops Mixture Containing Xanthohumol and Humulone
| Autor: | Hyung Joo Suh, Yejin Ahn, Byungjick Min, Kyungae Jo, Woong-Kwon Kwak, Hyeok-Jun Cho |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.drug_class
hop Pharmaceutical Science Saaz Pharmacology Non-rapid eye movement sleep Analytical Chemistry chemistry.chemical_compound QD241-441 Sapir xanthohumol humulone GABAA receptor Drug Discovery medicine Humulone Physical and Theoretical Chemistry Organic Chemistry Bicuculline GABA receptor antagonist chemistry Chemistry (miscellaneous) Sedative Xanthohumol Molecular Medicine medicine.drug Picrotoxin |
| Zdroj: | Molecules, Vol 26, Iss 7108, p 7108 (2021) Molecules; Volume 26; Issue 23; Pages: 7108 |
| ISSN: | 1420-3049 |
| Popis: | Hops contain flavonoids that have sedative and sleep-promoting activities such as α-acid, β-acid, and xanthohumol. In this study, the sleep-enhancing activity of a Saaz–Saphir hops mixture was measured. In the caffeine-induced insomnia model, the administration of a Saaz–Saphir mixture increased the sleep time compared to Saaz or Saphir administration alone, which was attributed to the increase in NREM sleep time by the δ-wave increase. Oral administration of the Saaz–Saphir mixture for 3 weeks increased the γ-amino butyric acid (GABA) content in the brain and increased the expression of the GABAA receptor. As the GABA antagonists picrotoxin and bicuculline showed a decrease in sleep activity, it was confirmed that the GABAA receptor was involved in the Saaz–Saphir mixture activity. In addition, the GABAA receptor antagonist also reduced the sleep activity induced by xanthohumol and humulone contained in the Saaz–Saphir mixture. Therefore, xanthohumol and humulone contained in the Saaz–Saphir mixture showed sleep-promoting activity mediated by the GABAA receptors. The mixture of the Saaz and Saphir hop varieties may thus help mitigate sleep disturbances compared to other hop varieties. |
| Databáze: | OpenAIRE |
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