Predicting Outcomes for Locally Advanced Rectal Cancer Treated With Neoadjuvant Chemoradiation With CT-Based Radiomics

Autor:	Sharon Shuxian Poh, Fuqiang Wang, Michael Lian Chek Wang, Boon Fei Tan, Wenlong Nei, Hong Qi Tan, Connie Yip, Faye Lynette Wei Tching Lim, Tian Rui Siow
Rok vydání:	2021
Předmět:	medicine.medical_specialty Multidisciplinary Rectal Neoplasms Colorectal cancer business.industry Rectum Locally advanced Neoplasms Second Primary Prognosis medicine.disease Neoadjuvant Therapy Radiomics medicine Humans Radiology Tomography X-Ray Computed business Retrospective Studies
DOI:	10.21203/rs.3.rs-751593/v1
Popis:	A feasibility study was performed to determine if CT-based radiomics could play an augmentative role in predicting neoadjuvant rectal score (NAR), locoregional failure free survival (LRFFS), distant metastasis free survival (DMFS), disease free survival (DFS) and overall survival (OS) in locally advanced rectal cancer (LARC). The NAR score, which takes into account the pathological tumour and nodal stage as well as clinical tumour stage, is a validated surrogate endpoint used for early determination of treatment response whereby a low NAR score ( 16) has been correlated with poorer outcomes. CT images of 191 patients with LARC were used in this study. Primary tumour (GTV) and mesorectum (CTV) were contoured separately and radiomics features were extracted from both segments. Two NAR models (NAR > 16 and NAR 16 and NAR 16 and NAR
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e9562705a7f469abd4f95ac3ecc9a80 https://doi.org/10.21203/rs.3.rs-751593/v1 Zobrazit plný text záznamu