Neuronal patterning of the tubular collar cord is highly conserved among enteropneusts but dissimilar to the chordate neural tube
| Autor: | Andreas Wanninger, Sabrina Kaul, Makoto Urata, Daniela Praher |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Most recent common ancestor Nervous system Neural Tube Body Patterning Science Developmental neurogenesis Chordate Homology (biology) Article 03 medical and health sciences 0302 clinical medicine medicine Animals Chordata 030304 developmental biology 0303 health sciences Multidisciplinary Deuterostome biology Gene Expression Profiling Neural tube Anatomy biology.organism_classification engrailed Cell biology Gene expression profiling 030104 developmental biology medicine.anatomical_structure Ventral nerve cord Medicine Evolutionary developmental biology PAX6 030217 neurology & neurosurgery |
| Zdroj: | Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017) Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | The dorsal neural tube of chordates and the ventral nerve cord of annelids exhibit a similar molecular mediolateral architecture. Accordingly, the presence of such a complex nervous system (CNS) has been proposed for their last common ancestor. Members of Enteropneusta, a group of non-chordate deuterostomes, possess a less complex CNS including a hollow neural tube, whereby homology to its chordate counterpart remains elusive. Since the majority of data on enteropneusts stem fromSaccoglossus kowalevskii,a derived direct-developer, we investigated expression of key neuronal patterning genes in the indirect-developerBalanoglossus misakiensis.The collar cord ofB. misakiensisshows anteriorSix3/6and posteriorOtx+engrailedexpression, in a region corresponding to the chordate brain. NeuronalNk2.1/Nk2.2expression is absent. Interestingly, we found medianDlxand lateralPax6expression domains, i.e., a condition that is reversed compared to chordates.Comparative analyses reveal that CNS patterning is highly conserved among enteropneusts.BmiDlxandBmiPax6have no corresponding expression domains in the chordate brain, which may be indicative of independent acquisition of a tubular CNS in Enteropneusta and Chordata. Moreover, mediolateral architecture varies considerably among chordates and enteropneusts, questioning the presence of a vertebrate-like patterned nervous system in the last common deuterostome ancestor. |
| Databáze: | OpenAIRE |
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