Chitosan microencapsulation of the dispersed phase of an O/W nanoemulsion to hydrochlorothiazide delivery

Autor:	Patricia de Oliveira Benedet, Jéssica Henriques Kruger, Aline Buttchevitz, Thiago Caon, Cassiana Mendes, Marcos Antonio Segatto Silva, Elenara Lemos-Senna
Rok vydání:	2017
Předmět:	Materials science Spectrophotometry Infrared Drug Compounding Pharmaceutical Science Bioengineering 02 engineering and technology Pharmacology 010402 general chemistry 01 natural sciences Wall material Chitosan chemistry.chemical_compound Colloid and Surface Chemistry Hydrochlorothiazide medicine Mucoadhesion Animals Rats Wistar Physical and Theoretical Chemistry Diuretics Antihypertensive Agents Drug compounding Calorimetry Differential Scanning Organic Chemistry Chromatography liquid 021001 nanoscience & nanotechnology Diuretic Activity Rats 0104 chemical sciences Solubility chemistry Chemical engineering Microscopy Electron Scanning Emulsions Female Spectrophotometry Ultraviolet Particulate system 0210 nano-technology Chromatography Liquid medicine.drug
Zdroj:	Journal of Microencapsulation. 34:611-622
ISSN:	1464-5246 0265-2048
DOI:	10.1080/02652048.2017.1373155
Popis:	In view of biopharmaceutical limitations of hydrochlorothiazide (HCTZ), Trojan-type mucoadhesive systems were proposed, aiming to improve HCTZ pharmacological properties by modulating its release. Nanoemulsions were formed spontaneously by combining medium-chain triglycerides (Lipoid® S75 and Pluronic® F68) and high encapsulation efficiency was obtained. The mucoadhesive properties were provided by chitosan and microencapsulation of nanoemulsions in spray-dryer was successfully achieved by using Aerosil® as wall material. The rapid redispersion of nanoemulsion in simulated fluids led to a fast and complete release of HCTZ in gastric medium. The pharmacodynamics of HCTZ was improved, extending the diuretic activity. Once a simple and low-energy method contributed to obtain stable mucoadhesive nanoemulsions, advantages in terms of production could also be achieved, allowing easy scaling up. This novel mucoadhesive Trojan particulate system of HCTZ showed to be a promising approach to overcome limitations in terms of absorption and consequently improve the therapeutic efficacy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e90679126cf3b8e5980b898e4ee8154 https://doi.org/10.1080/02652048.2017.1373155 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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