Collagen intrafibrillar mineralization as a result of the balance between osmotic equilibrium and electroneutrality
| Autor: | Ji Hong Bian, Mo Li, Sang Eun Jee, Lorenzo Breschi, Franklin R. Tay, Li Na Niu, Ji Hua Chen, Yao Dong Yang, Lige Tonggu, Liguo Wang, Seung Soon Jang, Kai Jiao, David H. Pashley |
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| Přispěvatelé: | Niu, Li-Na, Jee, Sang Eun, Jiao, Kai, Tonggu, Lige, Li, Mo, Wang, Liguo, Yang, Yao-Dong, Bian, Ji-Hong, Breschi, Lorenzo, Jang, Seung Soon, Chen, Ji-Hua, Pashley, David H., Tay, Franklin R. |
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Fibrillar collagen Fibrillar Collagens Static Electricity Condensed Matter Physic 02 engineering and technology Electrolyte Molecular Dynamics Simulation Article 03 medical and health sciences Electrolytes Osmotic Pressure Mechanics of Material General Materials Science Computer Simulation Minerals Chemistry Mechanical Engineering Chemistry (all) General Chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics Polyelectrolyte Collagen mineralization 030104 developmental biology Electrostatic attraction Biochemistry Mechanics of Materials Biophysics Materials Science (all) Intrafibrillar mineralization 0210 nano-technology |
| Zdroj: | Nature materials |
| ISSN: | 1476-4660 |
| Popis: | Mineralisation of fibrillar collagen with biomimetic process-directing agents has enabled scientists to gain insight into the potential mechanisms involved in intrafibrillar mineralisation. Here, by using polycation- and polyanion-directed intrafibrillar mineralisation, we challenge the popular paradigm that electrostatic attraction is solely responsible for polyelectrolyte-directed intrafibrillar mineralisation. Because there is no difference when a polycationic or a polyanionic electrolyte is used to direct collagen mineralisation, we argue that additional types of long-range non-electrostatic interactions are responsible for intrafibrillar mineralisation. Molecular dynamics simulations of collagen structures in the presence of extrafibrillar polyelectrolytes show that the outward movement of ions and intrafibrillar water through the collagen surface occurs irrespective of the charges of polyelectrolytes, resulting in the experimentally verifiable contraction of the collagen structures. The need to balance electroneutrality and osmotic equilibrium simultaneously to establish Gibbs-Donnan equilibrium in a polyelectrolyte-directed mineralisation system establishes a new model for collagen intrafibrillar mineralisation that supplements existing collagen mineralisation mechanisms. |
| Databáze: | OpenAIRE |
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