Tungsten disulfide-based nanocomposites for photothermal therapy
| Autor: | Jean-Paul Lellouche, Hagit Sade, Maayan Pour, Rina Ben-Shabbat Binyamini, Tzuriel Levin, Iftach Nachman |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
magnetic nanoparticles
Materials science photothermal therapy Biocompatibility Tungsten disulfide General Physics and Astronomy Nanoparticle Nanotechnology 02 engineering and technology 010402 general chemistry lcsh:Chemical technology 01 natural sciences lcsh:Technology Full Research Paper chemistry.chemical_compound General Materials Science lcsh:TP1-1185 Electrical and Electronic Engineering lcsh:Science surface functionalization chemistry.chemical_classification Nanocomposite lcsh:T WS2 nanotubes Polymer Photothermal therapy 021001 nanoscience & nanotechnology lcsh:QC1-999 0104 chemical sciences Nanoscience chemistry Surface modification Magnetic nanoparticles cerium complex lcsh:Q 0210 nano-technology lcsh:Physics |
| Zdroj: | Beilstein Journal of Nanotechnology, Vol 10, Iss 1, Pp 811-822 (2019) Beilstein Journal of Nanotechnology |
| ISSN: | 2190-4286 |
| Popis: | Nanostructures of transition-metal dichalcogenides (TMDC) have raised scientific interest in the last few decades. Tungsten disulfide (WS2) nanotubes and nanoparticles are among the most extensively studied members in this group, and are used for, e.g., polymer reinforcement, lubrication and electronic devices. Their biocompatibility and low toxicity make them suitable for medical and biological applications. One potential application is photothermal therapy (PTT), a method for the targeted treatment of cancer, in which a light-responsive material is irradiated with a laser in the near-infrared range. In the current article we present WS2 nanotubes functionalized with previously reported ceric ammonium nitrate–maghemite (CAN-mag) nanoparticles, used for PTT. Functionalization of the nanotubes with CAN-mag nanoparticles resulted in a magnetic nanocomposite. When tested in vitro with two types of cancer cells, the functionalized nanotubes showed a better PTT activity compared to non-functionalized nanotubes, as well as reduced aggregation and the ability to add a second-step functionality. This ability is demonstrated here with two polymers grafted onto the nanocomposite surface, and other functionalities could be additional cancer therapy agents for achieving increased therapeutic activity. |
| Databáze: | OpenAIRE |
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