Susceptibility and acquired immunity of two subspecies of cotton rats to their respective strains of filarial worm parasites
| Autor: | J. Allen Scott, L. J. Olson, Etta Macdonald |
|---|---|
| Rok vydání: | 1958 |
| Předmět: |
Strain (chemistry)
Immunology General Medicine Litomosoides carinii Adaptive Immunity Biology Subspecies Sigmodon hispidus Acquired immune system Rats Microbiology Infectious Diseases Retarded growth Immunity Helminths parasitic diseases Animals Parasites Parasitology Disease Susceptibility Sigmodontinae Nematode Infections Filarioidea |
| Zdroj: | Experimental Parasitology. 7:418-427 |
| ISSN: | 0014-4894 |
| DOI: | 10.1016/0014-4894(58)90037-7 |
| Popis: | Two subspecies of cotton rats, Sigmodon hispidus hispidus and S. h. texianus appear to be equally susceptible to primary infections of the two strains of filarial worms, Litomosoides carinii , which they harbor in nature. Acquired immunity as measured by retarded growth and development of worms of challenging infections as compared with those of primary infections, appears to develop equally in either strain of rat with either strain of worms. When the two strains of rats were immunized and challenged with the two strains of worms in all possible combinations, some slight differences were observed between strains of rats and between strains of parasites. The differences were large, however, when worms from immunized rats were compared with those from non-immunized rats, regardless of the strains of rats or the strain of immunizing or challenging worms. There may be some evidence of slight differences between the strains of worms in their adaptation to their respective geographically isolated hosts. The comparability of work using different strains, which has been published to date, does not appear to be invalidated. In future experiments comparisons should be made within strains and not between strains. |
| Databáze: | OpenAIRE |
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