Increased expression of microRNA miR-326 in type 1 diabetic patients with ongoing islet autoimmunity
| Autor: | Fabio Arturo Grieco, Francesco Dotta, Guido Sebastiani, Isabella Spagnuolo, Letizia Galleri, Dorica Cataldo |
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| Rok vydání: | 2011 |
| Předmět: |
Glutamate Decarboxylase -- immunology
medicine.medical_specialty Endocrinology Diabetes and Metabolism Autoimmunity medicine.disease_cause Calcitriol receptor Autoimmunity -- immunology Islets of Langerhans Endocrinology Internal medicine Internal Medicine medicine Humans Receptor-Like Protein Tyrosine Phosphatases Class 8 Autoantibodies -- immunology Autoantibodies Regulation of gene expression geography Type 1 diabetes geography.geographical_feature_category Oncogene biology Glutamate Decarboxylase business.industry Autoantibody Sciences bio-médicales et agricoles Islet medicine.disease MicroRNAs -- biosynthesis MicroRNAs Diabetes Mellitus Type 1 Immunology biology.protein Islets of Langerhans -- immunology Antibody Diabetes Mellitus Type 1 -- blood -- genetics business |
| Zdroj: | Diabetes/metabolism research and reviews, 27 (8 |
| ISSN: | 1520-7552 |
| DOI: | 10.1002/dmrr.1262 |
| Popis: | The current paradigm that microRNAs represent a new layer of gene regulation has generated much interest in this field. MicroRNAs have emerged as important regulatory factors involved in the developmental processes and in the regulation of insulin secretion and signalling. Furthermore, recent studies revealed an altered microRNA profiling in lymphocytes of patients with autoimmune diseases like multiple sclerosis, in which a hyperexpression of miR-326 was reported. Here, we analysed the expression levels of miR-326 in peripheral blood lymphocytes from type 1 diabetic (T1D) patients in relationship with ongoing islet autoimmunity. info:eu-repo/semantics/published |
| Databáze: | OpenAIRE |
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