Comparative effects of recombinant human insulin-like growth factor I and insulin on whole-body and forearm palmitate metabolism in man
| Autor: | Roland Laager, Ulrich Keller, Ronald Ninnis |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Blood Glucose Glycerol Male medicine.medical_specialty medicine.medical_treatment Glucose uptake Lipolysis Palmitates Biology Palmitic acid chemistry.chemical_compound Internal medicine medicine Humans Insulin Insulin-Like Growth Factor I Infusions Intravenous Saline Triglycerides Dose-Response Relationship Drug Growth factor Biological activity General Medicine Metabolism Recombinant Proteins Forearm Endocrinology chemistry |
| Zdroj: | Clinical science (London, England : 1979). 88(6) |
| ISSN: | 0143-5221 |
| Popis: | 1. The effects of intravenous infusions of recombinant human insulin-like growth factor 1 and insulin on palmitate kinetics, lipolysis and on serum triacylglycerol were compared. Overnight-fasted normal subjects received high doses of insulin-like growth factor I (30 μgh−1 kg−1) and insulin (0.23 nmol h−1 kg−1; group 1), low doses of insulin-like growth factor I (5 μg h−1 kg−1) and insulin (0.04 nmol h−1 kg−1; group 2) or saline (control group). The doses of insulin-like growth factor I and insulin were equipotent with regard to increases in glucose uptake during 8 h euglycaemic clamping. 2. Whole-body palmitate flux (measured by continuous infusions of [2,2-D2]palmitate) was lowered dose-dependently by 68% ± 6% during insulin-like growth factor I and by 82% ± 2% during insulin after 8 h of infusions of high doses (insulin-like growth factor I versus insulin; not significant). Plasma palmitate, glycerol and triacylglycerol concentrations had decreased to a similar extent at the end of the infusions of both peptides at either dose. 3. The present results demonstrate that insulin-like growth factor I and insulin infused at doses which result in identical increases in glucose uptake during euglycaemic clamping are equipotent inhibitors of lipolysis. |
| Databáze: | OpenAIRE |
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