Insulin-like growth factor binding protein-3, in association with IGF-1 receptor, can predict prognosis in squamous cell carcinoma of the head and neck
| Autor: | Jeong-Hwan Baek, Myung-Ju Ahn, Keunchil Park, Jong-Mu Sun, Yeon Hee Park, Young-Ik Son, Young Hyeh Ko, Hyun Jung Jun, Yong Chan Ahn |
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| Rok vydání: | 2011 |
| Předmět: |
Oncology
Adult Male Cancer Research medicine.medical_specialty Multivariate analysis Insulin-like growth factor-binding protein Receptor IGF Type 1 Internal medicine medicine Carcinoma Biomarkers Tumor Humans Basal cell Head and neck Receptor Aged Retrospective Studies Aged 80 and over biology business.industry Retrospective cohort study Middle Aged medicine.disease Prognosis Insulin-Like Growth Factor Binding Protein 3 Head and Neck Neoplasms biology.protein Carcinoma Squamous Cell Disease Progression Immunohistochemistry Female Oral Surgery business |
| Zdroj: | Oral oncology. 47(8) |
| ISSN: | 1879-0593 |
| Popis: | The aim of this study was to investigate the prognostic role of insulin-like growth factor-1 receptor (IGF-1R) and IGF binding protein-3 (IGFBP-3) in patients with squamous cell carcinoma of the head and neck (SCCHN). The clinical data of 131 SCCHN patients who had undergone surgical resection were retrospectively reviewed, and their intratumoral expression of IGF-1R and IGFBP-3 was evaluated by immunohistochemistry. Thirty-six cases (27.5%) experienced tumor recurrence during the median follow-up period of 53.7months (95% CI, 19.0-90.7months). IGF-1R-positivity and IGFBP-3-positivity were observed in 96 (73.3%) and 70 cases (53.4%), respectively. IGFBP-3-positivity was associated with shorter time to progression (TTP) by univariate (P=0.03) and multivariate analyses (95% CI, 0.23-0.91), whereas IGF-1R itself failed to show its prognostic relevance. However, it was revealed that the prognostic role of IGFBP-3 expression was dependent on IGF-1R expression in the analysis of four subgroups classified according to IGF-1R and IGFBP-3 expression: the IGF-1R-positive/IGFBP-3-positive subgroup was the best prognostic group, while the IGF-1R-negative/IGFBP-3-positive subgroup was the worst in terms of TTP (P=0.017). In conclusion, it is suggested that IGFBP-3 expression, in a state of co-expression with IGF-1R, can predict poor prognosis in SCCHN patients. |
| Databáze: | OpenAIRE |
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