Unique Inflammatory Mediators and Specific IgE Levels Distinguish Local from Systemic Reactions after Anthrax Vaccine Adsorbed Vaccination
| Autor: | Kenneth J. Smith, Lori Garman, Judith A. James, Melissa E. Munroe, Christina E. Spooner, Renata J.M. Engler, Cathy A. Velte, Emily E. Muns, Michael R. Nelson, A. Darise Farris |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine Microbiology (medical) Adolescent Drug-Related Side Effects and Adverse Reactions Bacterial Toxins Clinical Biochemistry Immunology Anthrax Vaccines Immunoglobulin E Systemic inflammation Young Adult 03 medical and health sciences Sex Factors 0302 clinical medicine Ethnicity medicine Humans Immunology and Allergy 030212 general & internal medicine Hepatitis Antigens Bacterial Vaccines biology business.industry C-reactive protein Age Factors Anthrax Vaccine Adsorbed Odds ratio Middle Aged medicine.disease Antibodies Bacterial United States Chemokine CXCL10 Vaccination C-Reactive Protein 030104 developmental biology Cohort biology.protein Female medicine.symptom business |
| Zdroj: | Clinical and Vaccine Immunology. 23:664-671 |
| ISSN: | 1556-679X 1556-6811 |
| Popis: | Although the U.S. National Academy of Sciences concluded that anthrax vaccine adsorbed (AVA) has an adverse event (AE) profile similar to those of other adult vaccines, 30 to 70% of queried AVA vaccinees report AEs. AEs appear to be correlated with certain demographic factors, but the underlying immunologic pathways are poorly understood. We evaluated a cohort of 2,421 AVA vaccinees and found 153 (6.3%) reported an AE. Females were more likely to experience AEs (odds ratio [OR] = 6.0 [95% confidence interval {CI} = 4.2 to 8.7]; P < 0.0001). Individuals 18 to 29 years of age were less likely to report an AE than individuals aged 30 years or older (OR = 0.31 [95% CI = 0.22 to 0.43]; P < 0.0001). No significant effects were observed for African, European, Hispanic, American Indian, or Asian ancestry after correcting for age and sex. Additionally, 103 AEs were large local reactions (LLRs), whereas 53 AEs were systemic reactions (SRs). In a subset of our cohort vaccinated 2 to 12 months prior to plasma sample collection ( n = 75), individuals with LLRs ( n = 33) had higher protective-antigen (PA)-specific IgE levels than matched, unaffected vaccinated individuals ( n = 50; P < 0.01). Anti-PA IgE was not associated with total plasma IgE, hepatitis B-specific IgE, or anti-PA IgG in individuals who reported an AE or in matched, unaffected AVA-vaccinated individuals. IP-10 was also elevated in sera of individuals who developed LLRs ( P < 0.05). Individuals reporting SRs had higher levels of systemic inflammation as measured from C-reactive protein ( P < 0.01). Thus, LLRs and SRs are mediated by distinct pathways. LLRs are associated with a vaccine-specific IgE response and IP-10, whereas SRs demonstrate increased systemic inflammation without a skewed cytokine profile. |
| Databáze: | OpenAIRE |
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