Combined Norepinephrine / Serotonergic Reuptake Inhibition: Effects on Maternal Behavior, Aggression and Oxytocin in the Rat
| Autor: | Elizabeth Thomas Cox, Thomas Merryfield Jarrett, Matthew Stephen McMurray, Kevin eGreenhill, Vivian E Hofler, Sarah Kaye Williams, Paul Wayland Joyner, Christopher L Middleton, Cheryl H Walker, Josephine M Johns |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Serotonin lcsh:RC435-571 Amitriptyline Oxytocin Reuptake 03 medical and health sciences Norepinephrine 0302 clinical medicine Internal medicine Desipramine lcsh:Psychiatry medicine Maternal Behavior Original Research Psychiatry Monoamine transporter biology 3. Good health 030227 psychiatry Psychiatry and Mental health Endocrinology Monoamine neurotransmitter Norepinephrine transporter biology.protein Reuptake inhibitor Psychology 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Frontiers in Psychiatry, Vol 2 (2011) Frontiers in Psychiatry |
| ISSN: | 1664-0640 |
| Popis: | BACKGROUND: Few systematic studies exist on the effects of chronic reuptake of monoamine neurotransmitter systems during pregnancy on the regulation of maternal behavior, although many drugs act primarily through one or more of these systems. Previous studies examining fluoxetine and amfonelic acid treatment during gestation on subsequent maternal behavior in rodents indicated significant alterations in postpartum maternal care, aggression and oxytocin levels. In this study, we extended our studies to include chronic gestational treatment with desipramine or amitriptyline to examine differential effects of reuptake inhibition of norepinephrine and combined noradrenergic and serotonergic systems on maternal behavior, aggression, and oxytocin system changes. METHODS: Pregnant Sprague-Dawley rats were treated throughout gestation with saline or one of three doses of either desipramine, which has a high affinity for the norepinephrine monoamine transporter, or amitriptyline, an agent with high affinity for both the norepinephrine and serotonin monoamine transporters. Maternal behavior and postpartum aggression were assessed on postpartum days one and six respectively. Oxytocin levels were measured in relevant brain regions on postpartum day seven. Predictions were that amitriptyline would decrease maternal behavior and increase aggression relative to desipramine, particularly at higher doses. Amygdaloidal oxytocin was expected to decrease with increased aggression. RESULTS: Amitriptyline and desiprimine differentially reduced maternal behavior, and at higher doses reduced aggressive behavior. Hippocampal oxytocin levels were lower after treatment with either drug but were not correlated with specific behavioral effects. These results, in combination with previous findings following gestational treatment with other selective neurotransmitter reuptake inhibitors, highlight the diverse effects of multiple monoamine systems thought to be involved in maternal care. |
| Databáze: | OpenAIRE |
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