Physiological Basis of Cochlear Transduction and Sensitivity
| Autor: | Vicente Honrubia, Stephan T. Sitko, David Strelioff |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
medicine.medical_specialty
Xenopus Guinea Pigs Audiology Models Biological Cochlear function 03 medical and health sciences 0302 clinical medicine Hair Cells Auditory otorhinolaryngologic diseases Animals Medicine Neurons Afferent Sensitivity (control systems) 030223 otorhinolaryngology Cochlea biology business.industry General Medicine Vestibulocochlear Nerve biology.organism_classification Electrophysiology medicine.anatomical_structure Energy Transfer Otorhinolaryngology 030220 oncology & carcinogenesis sense organs Hair cell business Guinea pig cochlea Transduction (physiology) Neuroscience |
| Zdroj: | Annals of Otology, Rhinology & Laryngology. 85:697-710 |
| ISSN: | 1943-572X 0003-4894 |
| DOI: | 10.1177/000348947608500601 |
| Popis: | Experiments were conducted in the guinea pig cochlea and the Xenopus laevis lateral line organ to obtain information about the electrical impedance properties of the cochlea, the sources and characteristics of the cochlear potentials, and to determine if hair cells are electrically excitable. The significance of the resting and evoked cochlear potentials in the transduction process leading to excitation of the acoustic nerve fibers was evaluated by comparing the results of electrophysiological experiments with the prediction of a model of the cochlea designed after the mechanoelectric theory of hair cell function. The results of these experiments 1) were compatible with the prediction of the mechoelectric theory of cochlear function; 2) made it possible to estimate and compare the energy dissipated in generating and maintaining the cochlear potentials with the stores of biochemical energy available in the cochlea; and 3) showed that the hair cells are electrically excitable, from which it was concluded that interaction between the hair cells is feasible. |
| Databáze: | OpenAIRE |
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