On the occurrence and enigmatic functions of mixed (chemical plus electrical) synapses in the mammalian CNS
| Autor: | Alberto E. Pereda, James I. Nagy, John E. Rash |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Central Nervous System Neurotransmission Biology Neuronal circuitry Synaptic Transmission Connexins Article 03 medical and health sciences 0302 clinical medicine Mauthner cell Electrical Synapses medicine Animals Axon Mammals Neurons General Neuroscience Gap junction Gap Junctions Autonomic nervous system 030104 developmental biology medicine.anatomical_structure nervous system Structural composition Synapses Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neuroscience letters. 695 |
| ISSN: | 1872-7972 |
| Popis: | Electrical synapses with diverse configurations and functions occur at a variety of interneuronal appositions, thereby significantly expanding the physiological complexity of neuronal circuitry over that provided solely by chemical synapses. Gap junctions between apposed dendritic and somatic plasma membranes form “purely electrical” synapses that allow for electrical communication between coupled neurons. In addition, gap junctions at axon terminals synapsing on dendrites and somata allow for “mixed” (dual chemical + electrical) synaptic transmission. “Dual transmission” was first documented in the autonomic nervous system of birds, followed by its detection in the central nervous systems of fish, amphibia, and reptiles. Subsequently, mixed synapses have been detected in several locations in the mammalian CNS, where their properties and functional roles remain undetermined. Here, we review available evidence for the presence, complex structural composition, and emerging functional properties of mixed synapses in the mammalian CNS. |
| Databáze: | OpenAIRE |
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