The Application and Teaching Value of a Ventricular Septal Defect Canine Model Established by Transcatheter Puncture
| Autor: | Tong Kan, Ya-Wei Yang, Xin-miao Huang, Yong-Wen Qin, Wei Zhang, Ji-de Lu, Guo-Jun Chu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Heart Septal Defects
Ventricular Male congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Cardiac Catheterization medicine.medical_treatment Perforation (oil well) Hemodynamics Punctures 030204 cardiovascular system & hematology Balloon dilatation 03 medical and health sciences 0302 clinical medicine Dogs medicine Animals 030212 general & internal medicine Thoracotomy Cardiac Surgical Procedures Heart septal defect medicine.diagnostic_test business.industry Teaching General Medicine medicine.disease Surgery Catheter Disease Models Animal Education Medical Graduate Fluoroscopy Angiography Female Cardiology and Cardiovascular Medicine business Canine model |
| Zdroj: | International heart journal. 62(2) |
| ISSN: | 1349-3299 |
| Popis: | This study aimed to improve and further explore a ventricular septal defect (VSD) canine model on the basis of the transcatheter puncture method and to evaluate its application and teaching value.In order to lessen the complications of VSD closure, it is necessary to improve the currently available treatment devices using appropriate animal models.In this study, we used 16 healthy adult canines as our models. After anesthesia, the VSD puncture was performed, followed by balloon dilatation of the perforation. VSD was confirmed by angiography. The venous-artery orbit was established, and the VSD was then closed once the catheter and occluder were across the defect.Of the experimental canines, 14 of the 16 canines were successfully modeled, giving a success rate of 87.5%. The canines underwent an immediate creation of a venous-artery orbit for teaching practice and were implanted with an occluder during the procedure. After 4 weeks, 13 canines survived. As per our findings, most VSD types established by the puncture were perimembranous (10 of 13, 77%).The current model has a high success rate. The model can not only avoid the risk of infection and hemodynamic disorders associated with an open thoracotomy, but can also be effectively used in evaluating the impact of occluders. It can also directly measure the parameters of the devices during the procedure, thus having a very high experimental and teaching value. |
| Databáze: | OpenAIRE |
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