Pulmonary Delivery of Theranostic Nanoclusters for Lung Cancer Ferroptosis with Enhanced Chemodynamic/Radiation Synergistic Therapy

Autor:	Yingbo Li, Jie Yang, Guangying Gu, Xu Guo, Chunbo He, Jiemei Sun, Hongyan Zou, Hongbin Wang, Shuang Liu, Xiaona Li, Shujun Zhang, Kai Wang, Lili Yang, Ying Jiang, Lina Wu, Xilin Sun
Rok vydání:	2022
Předmět:	Lung Neoplasms Mechanical Engineering Bioengineering Hydrogen Peroxide General Chemistry Condensed Matter Physics Cell Line Tumor Neoplasms Tumor Microenvironment Ferroptosis Humans Nanoparticles General Materials Science Precision Medicine
Zdroj:	Nano Letters. 22:963-972
ISSN:	1530-6992 1530-6984
Popis:	Inefficient tumor accumulation and penetration remain as the main challenges to therapy efficacy of lung cancer. Local delivery of smart nanoclusters can increase drug penetration and provide superior antitumor effects than systemic routes. Here, we report self-assembled pH-sensitive superparamagnetic iron oxide nanoclusters (SPIONCs) that enhance
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e7c6220f4ec54b6c65d4b6e7baa4cad https://doi.org/10.1021/acs.nanolett.1c03786 Zobrazit plný text záznamu