Chemistry and Toxicology of Major Bioactive Substances in Inocybe Mushrooms
Autor: | Eugenie Nepovimova, Jiri Patocka, Ran Wu, Kamil Kuca, Martin Vališ, Wenda Wu |
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Rok vydání: | 2021 |
Předmět: |
Inocybe mushroom
muscarine Review Mushroom Poisoning medicine.disease_cause 030226 pharmacology & pharmacy Psilocybin lcsh:Chemistry Toxicology chemistry.chemical_compound 0302 clinical medicine Lectins Mushroom poisoning lcsh:QH301-705.5 Spectroscopy biology food and beverages General Medicine Tryptamines Computer Science Applications Psilocin toxicology medicine.drug animal structures Catalysis Inorganic Chemistry 03 medical and health sciences Organophosphorus Compounds medicine Animals Humans Physical and Theoretical Chemistry psilocin psilocybin Molecular Biology Inocybe Muscarine Toxin fungi Organic Chemistry biology.organism_classification medicine.disease Baeocystin lcsh:Biology (General) lcsh:QD1-999 nervous system chemistry Aeruginascin Agaricales 030217 neurology & neurosurgery |
Zdroj: | International Journal of Molecular Sciences, Vol 22, Iss 2218, p 2218 (2021) International Journal of Molecular Sciences |
ISSN: | 1422-0067 |
DOI: | 10.3390/ijms22042218 |
Popis: | Mushroom poisoning has always been a threat to human health. There are a large number of reports about ingestion of poisonous mushrooms every year around the world. It attracts the attention of researchers, especially in the aspects of toxin composition, toxic mechanism and toxin application in poisonous mushroom. Inocybe is a large genus of mushrooms and contains toxic substances including muscarine, psilocybin, psilocin, aeruginascin, lectins and baeocystin. In order to prevent and remedy mushroom poisoning, it is significant to clarify the toxic effects and mechanisms of these bioactive substances. In this review article, we summarize the chemistry, most known toxic effects and mechanisms of major toxic substances in Inocybe mushrooms, especially muscarine, psilocybin and psilocin. Their available toxicity data (different species, different administration routes) published formerly are also summarized. In addition, the treatment and medical application of these toxic substances in Inocybe mushrooms are also discussed. We hope that this review will help understanding of the chemistry and toxicology of Inocybe mushrooms as well as the potential clinical application of its bioactive substances to benefit human beings. |
Databáze: | OpenAIRE |
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