Prevalence of cryoglobulinemia in hepatitis C virus (HCV) positive patients with and without human immunodeficiency virus (HIV) coinfection
| Autor: | Richard S. Garfein, Thania Cabrera, Charlene S. Dezzutti, James H. Marshall, Michael A. Purdy, David Vlahov, Jacquie Astemborski, David L. Thomas |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Hepatitis C virus Hepacivirus HIV Infections medicine.disease_cause Acquired immunodeficiency syndrome (AIDS) Virology Prevalence medicine Humans biology business.industry virus diseases Hepatitis C Viral Load medicine.disease biology.organism_classification Cryoglobulinemia Infectious Diseases Immunology Lentivirus HIV-1 Coinfection RNA Viral Female business Viral load |
| Zdroj: | Journal of Clinical Virology. 31:210-214 |
| ISSN: | 1386-6532 |
| Popis: | Coinfection with human immunodeficiency virus (HIV) has been shown to influence the natural history of hepatitis C infection.Our interest was to determine if HIV coinfection influences the prevalence of cryoglobulinemia in hepatitis C virus (HCV) infected persons.A total of 384 HCV RNA positive (234 HIV-infected and 150 HIV-uninfected) participants were tested at two visits, 18 months apart, for HCV and HIV RNA, CD4, and liver enzyme levels. Serum cryoglobulin levels were measured at a subsequent visit for a subset of the sample.HIV-infected participants had significantly higher HCV RNA levels (P0.0001) and aspartate transaminase (AST) levels (P0.0001), but not alanine transaminase (ALT) levels (P0.05) as compared with HIV-uninfected participants. These findings were consistent at both visits and no significant changes were observed between visits. Fifty (19%) of the 264 participants tested had detectable cryoglobulins. No difference was observed in HIV seropositivity among participants with or without cryoglobulinemia (68% versus 61%; odds ratio = 1.34, P = 0.37). However, among HIV coinfected participants, elevated AST levels (P = 0.04) and lower CD4 levels (P = 0.02) were associated with cryoglobulinemia.While previously reported associations were found between HIV and coinfection with HCV in this study, we did not find an association between HIV infection and cryoglobulinemia. |
| Databáze: | OpenAIRE |
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