The splicing regulatory factor hnRNPU is a novel transcriptional target of c-Myc in hepatocellular carcinoma
| Autor: | Biao Zhang, Hai-Yang Wang, Wen Yue, Jiafei Xi, Junnian Zhou, Xuetao Pei, De-Xi Zhao, Xue Nan, Lijuan He, Quan Zeng, Dong-Xing Wang |
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| Rok vydání: | 2020 |
| Předmět: |
Poor prognosis
Carcinoma Hepatocellular Transcription Genetic Biophysics Apoptosis Heterogeneous-Nuclear Ribonucleoprotein U Mice SCID Biology Biochemistry Proto-Oncogene Proteins c-myc 03 medical and health sciences Structural Biology Mice Inbred NOD Cell Line Tumor Genetics medicine Animals Humans neoplasms Molecular Biology 030304 developmental biology 0303 health sciences Messenger RNA 030302 biochemistry & molecular biology High mortality Liver Neoplasms Cell Biology Regulatory loop medicine.disease Xenograft Model Antitumor Assays digestive system diseases Hepatocellular carcinoma RNA splicing Cancer research Liver cancer |
| Zdroj: | FEBS lettersReferences. 595(1) |
| ISSN: | 1873-3468 |
| Popis: | Hepatocellular carcinoma (HCC) is the most common liver cancer with high mortality. Here, we found that hnRNPU is overexpressed in HCC tissues and is correlated with the poor prognosis of HCC patients. Besides, hnRNPU is of high significance in regulating the proliferation, apoptosis, self-renewal, and tumorigenic potential of HCC cells. Mechanismly, c-Myc regulates hnRNPU expression at the transcriptional level, and meanwhile, hnRNPU stabilizes the mRNA of c-MYC. We found that the hnRNPU and c-Myc regulatory loop exerts a synergistic effect on the proliferation and self-renewal of HCC, and promotes the HCC progression. Taken together, hnRNPU functions as a novel transcriptional target of c-Myc and promotes HCC progression, which may become a promising target for the treatment of c-Myc-driven HCC. |
| Databáze: | OpenAIRE |
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